| Identification | Back Directory | [Name]
3-[5-({3-[2-(4-fluoroanilino)-2-oxoethyl]-2,4-dioxo-1,3-thiazolidin-5-ylidene}methyl)-2-furyl]-2-methylbenzoic acid | [CAS]
592539-21-4 | [Synonyms]
ZINC17167211
ZINC-17167211
ZINC 17167211
3-[5-({3-[2-(4-fluoroanilino)-2-oxoethyl]-2,4-dioxo-1,3-thiazolidin-5-ylidene}methyl)-2-furyl]-2-methylbenzoic acid | [Molecular Formula]
C24H17FN2O6S | [MOL File]
592539-21-4.mol | [Molecular Weight]
480.465 |
| Hazard Information | Back Directory | [Description]
ZINC17167211 is a selective agonist of peroxisome proliferator activated receptors-α (PPAR-α). | [Uses]
ZINC17167211 is a potent PPAR-α agonist (EC50=0.16 nM) that can be used in the study of diabetes, hyperlipidemia, and inflammatory diseases[1]. | [IC 50]
PPAR-α: 0.16 nM (EC50) | [References]
[1] Gangwal, et al. "Biological evaluation and structural insights for design of subtype-selective peroxisome proliferator activated receptor-α (PPAR-α) agonists." Bioorganic & Medicinal Chemistry Letters 25.2 (2015): 270-275. DOI:10.1016/j.bmcl.2014.11.052 |
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