| Identification | Back Directory | [Name]
L-arginine [2S-[2alpha,5alpha,6beta(S*)]]-6-[amino(p-hydroxyphenyl)acetamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate | [CAS]
59261-05-1 | [Synonyms]
Amoxycillin arginine salt
Amoxycillin L-arginine salt
L-arginine [2S-[2alpha,5alpha,6beta(S*)]]-6-[amino(p-hydroxyphenyl)acetamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate | [EINECS(EC#)]
261-680-4 | [Molecular Formula]
C22H33N7O7S | [MOL File]
59261-05-1.mol | [Molecular Weight]
539.605 |
| Hazard Information | Back Directory | [Uses]
Amoxicillin (Amoxycillin) arginine is an antibiotic with good oral absorption and broad spectrum antimicrobial activity. Amoxicillin arginine inhibits the biosynthesis of polypeptides in the cell wall, thereby inhibiting cell growth[1][2][3]. | [in vivo]
Amoxicillin (Amoxycillin) arginine (7 mg/kg; i.h.; female ICR/Swiss mice) inhibits strain numbers and improves the survival rate of rats in 1 mg/L or less[2].
Amoxicillin (Amoxycillin) arginine (1.6-9.5 mg/kg; p.o.; daily, for 7 or 14 days; swiss albino mice) has against infection with chlamydia trachomatis in mice[3]. | Animal Model: | Female ICR/Swiss mice[2] | | Dosage: | 7 mg/kg | | Administration: | Subcutaneous injection; every 8 h, for 24 hours | | Result: | Inhibited bacterial numbers in a dose-dependent manner. |
| Animal Model: | Female ICR/Swiss mice[2] | | Dosage: | 7 mg/kg | | Administration: | Subcutaneous injection; every 8 h, for 4 days | | Result: | Survived all animals that were infected with organisms for which MICs were 1 mg/L or less, and with the two strains for which MICs were 2 mg/L, 20 to 40% mortality. |
| Animal Model: | Swiss albino mice[3] | | Dosage: | 1.6 and 9.5 mg/kg | | Administration: | Oral administration; daily, for 7 or 14 days | | Result: | Improved the activity of Chlamydia trachomatis infection in mice. |
| [References]
[1] Guo Y, et, al. Metabolic response of Lactobacillus acidophilus exposed to amoxicillin. J Antibiot (Tokyo). 2022 May;75(5):268-281. DOI:10.1038/s41429-022-00518-6
[2] Andes D, et, al. In vivo activities of amoxicillin and amoxicillin-clavulanate against Streptococcus pneumoniae: application to breakpoint determinations. Antimicrob Agents Chemother. 1998 Sep;42(9):2375-9. DOI:10.1128/AAC.42.9.2375
[3] Kramer MJ, et, al. Activity of oral amoxicillin, ampicillin, and oxytetracycline against infection with chlamydia trachomatis in mice. J Infect Dis. 1979 Jun;139(6):717-9. DOI:10.1093/infdis/139.6.717 |
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