| Identification | Back Directory | [Name]
Integrin Antagonists 27 | [CAS]
593274-97-6 | [Synonyms]
CS-2067
Integrin-IN-27
Integrin Antagonist 27
Integrin Antagonists 27
Benzoic acid, 3-[2-[[1-[2-[(4-methylphenyl)amino]-2-oxoethyl]-2,5-dioxo-4-imidazolidinylidene]methyl]-1H-pyrrol-1-yl]- | [Molecular Formula]
C24H20N4O5 | [MDL Number]
MFCD06663195 | [MOL File]
593274-97-6.mol | [Molecular Weight]
444.44 |
| Chemical Properties | Back Directory | [density ]
1.38±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: ≥ 100 mg/mL (225.00 mM) | [form ]
Solid | [pka]
3.69±0.10(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
Integrin antagonist 27 is a small molecule integrin αvβ3 antagonist with binding affinity of 18 nM, as s novel anticancer agent.
Target: Integrin
in vitro: Integrin antagonist 27 is treated with a panel of cancer cell-lines (breast cancer cell line MDA-MB-435, breast cancer cell lines MCF-7, mouse fibroblast NIH3T3, ovarian cancer cell line HEY, lung cancer cell line NCI-H1975) with all IC50 of >20 uM. | [References]
[1] Dayam R, et al. Discovery of small molecule integrin alphavbeta3 antagonists as novel anticancer agents. J Med Chem. 2006 Jul 27;49(15):4526-4534. DOI:10.1021/jm051296s |
|
| Company Name: |
Musechem
|
| Tel: |
+1-800-259-7612 |
| Website: |
www.musechem.com |
| Company Name: |
Cckinase, Inc.
|
| Tel: |
+1 (732)236-3202 |
| Website: |
www.cckinase.com |
| Company Name: |
BOC Sciences
|
| Tel: |
16314854226 |
| Website: |
www.bocsci.com |
| Company Name: |
Biorbyt Ltd.
|
| Tel: |
+44 (0)1223 859 353 |
| Website: |
http://www.biorbyt.com |
|