| Identification | Back Directory | [Name]
CALCIMYCIN HEMICALCIUM SALT | [CAS]
59450-89-4 | [Synonyms]
A23187 HEMICALCIUM SALT
CALCIMYCIN A23187 HEMICALCIUM SALT
Antibiotic A-23187 hemicalcium salt
calcium ionophore A23187 hemicalcium
CALCIUM IONOPHORE A23187 HEMICALCIUM SALT
Calcium Ionophore A23187 hemicalcium salt powder
CALCIUM IONOPHORE A23187 HEMICALCIUM SALT BIOCHEMIKA
A23187 hemicalcium salt, Antibiotic A 23187 hemicalcium salt, Calcimycin hemicalcium salt, Calimycin hemicalcium salt
5-(methylamino)-2-[[(2S,3R,5R,8R,9R)-3,5,9-trimethyl-2-[(2S)-1-oxo-1-(1H-pyrrol-2-yl)propan-2-yl]-1,7-dioxaspiro[5.5]undecan-8-yl]methyl]-1,3-benzoxazole-4-carboxylate
5-(methylamino)-2-[[(2S,3R,5R,6S,8R,9R)-3,5,9-trimethyl-2-[(2S)-1-oxo-1-(1H-pyrrol-2-yl)propan-2-yl]-1,7-dioxaspiro[5.5]undecan-8-yl]methyl]-1,3-benzoxazole-4-carboxylate | [Molecular Formula]
C58H72CaN6O12 | [MDL Number]
MFCD00077678 | [MOL File]
59450-89-4.mol | [Molecular Weight]
1085.3 |
| Hazard Information | Back Directory | [Uses]
Ionophore highly selective for Ca2+. Potentiates responses to NMDA but not quisqualate. In cell culture, stimulates nitric oxide production by calmodulin-dependent constitutive nitric oxide synthase. | [in vivo]
Calcimycin hemicalcium salt (A-23187 calcium) (2.5 or 7.5 nM; intrapleurally) induces protein leakage[5]. | Animal Model: | Mice (ICR, 25-30 g)[5] | | Dosage: | 2.5 or 7.5 nM | | Administration: | Intrapleurally | | Result: | Two hours after 2.5 nM, or 3 hours after 7.5 nM, challenge the protein levels in the pleural cavity were equivalent to about a half of their corresponding peak values.
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