| Identification | Back Directory | [Name]
1-Butanone, 4-[4-(4-bromophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)-, hydrochloride (1:1) | [CAS]
59453-24-6 | [Synonyms]
1-Butanone, 4-[4-(4-bromophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)-, hydrochloride (1:1) | [Molecular Formula]
C21H24BrClFNO2 | [MOL File]
59453-24-6.mol | [Molecular Weight]
456.78 |
| Hazard Information | Back Directory | [Uses]
Bromperidol (R-11333) hydrochloride possesses antipsychotic activity, with a high affinity for central dopamine receptors D2. Bromperidol hydrochloride can kill Mycobacteria in a synergistic manner with Spectinomycin[1][2]. | [in vivo]
Bromperidol hydrochloride antagonises stereotyped behaviour and agitation induced by apomorphine or amphetamine, and inhibits conditioned reactions and learned intracranial self-stimulation in rats[1].
Bromperidol hydrochloride antagonises apomorphine-induced emesis and inhibits the conditioned avoidance response in dogs[1]. | [IC 50]
D2 Receptor | [References]
[1] Benfield P, et al. Bromperidol. A preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in psychoses. Drugs. 1988 Jun;35(6):670-84. DOI:10.2165/00003495-198835060-00004
[2] Ramón-García S, et al. Synergistic drug combinations for tuberculosis therapy identified by a novel high-throughput screen. Antimicrob Agents Chemother. 2011 Aug;55(8):3861-9. DOI:10.1128/AAC.00474-11 |
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