| Identification | Back Directory | [Name]
ethyl 4-(4-hydroxy-3-methoxyphenyl)-2-mercapto-6-methyl-1,4-dihydropyrimidine-5-carboxylate | [CAS]
5948-75-4 | [Synonyms]
gp120-IN-1
ethyl 4-(4-hydroxy-3-methoxyphenyl)-2-mercapto-6-methyl-1,4-dihydropyrimidine-5-carboxylate
5-Pyrimidinecarboxylic acid, 1,2,3,4-tetrahydro-4-(4-hydroxy-3-methoxyphenyl)-6-methyl-2-thioxo-, ethyl ester | [Molecular Formula]
C15H18N2O4S | [MDL Number]
MFCD02331148 | [MOL File]
5948-75-4.mol | [Molecular Weight]
322.38 |
| Hazard Information | Back Directory | [Uses]
gp120-IN-1 (compound 4e) is a potent HIV-1 gp120 inhibitor with an IC50 of 2.2 μM and CC50 of 100.90 μM. gp120-IN-1 shows anti-HIV-1 activity. gp120-IN-1 shows cytotoxicity in a dose dependent manner in SUP-T1 cells. gp120-IN-1 shows inhibition of gp120-mediated virus enter into cells[1]. | [IC 50]
HIV-1: 2.2 μM (IC50); HIV-1: 100.90 μM (CC50) | [References]
[1] Senapathi J, et al. Design, Synthesis, and Antiviral activity of 1,2,3,4-Tetrahydropyrimidine derivatives acting as novel entry inhibitors to target at "Phe43 cavity" of HIV-1 gp120. Bioorg Med Chem. 2021 Dec 15;52:116526. DOI:10.1016/j.bmc.2021.116526 |
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