| Identification | Back Directory | [Name]
Cephalexin (hydrochloride) | [CAS]
59695-59-9 | [Synonyms]
Cephalexin (hydrochloride)
(6R,7R)-7-[[(2R)-Aminophenylacetyl]amino]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid monohydrochloride (1:1) | [Molecular Formula]
C16H18ClN3O4S | [MDL Number]
MFCD08141797 | [MOL File]
59695-59-9.mol | [Molecular Weight]
383.85 |
| Hazard Information | Back Directory | [Uses]
Cephalexin (Cefalexin) hydrochloride is a potent, orally active new semisynthetic cephalosporin antibiotic with a broad antibacterial spectrum. Cephalexin (Cefalexin) hydrochloride has antibacterial activity against a wide variety of gram-positive and gram-negative bacteria. Cephalexin (Cefalexin) hydrochloride targets penicillin-binding proteins (PBPs) to inhibit bacterial cell wall assembly. Cephalexin (Cefalexin) hydrochloride is used for the research of pneumonia, strep throat, and bacterial endocarditis, et al[1][2]. | [in vivo]
Cephalexin (Cefalexin) hydrochloride (0-50 mg/kg; p.o.; for 3.5 hours) has antibacterial activity in male Swiss-Webster mice with infected bacterial[2]. | Animal Model: | Male Swiss-Webster mice with infected bacterial[2] | | Dosage: | 0-50 mg/kg | | Administration: | Oral administration; for 3.5 hours | | Result: | Had antibacterial activity against Streptococcus pyogenes, Streptococcus pneumoniae, Staphylococcus aureus and several gram-negative species mice. |
| [IC 50]
β-lactam | [storage]
Store at -20°C | [References]
[1] Cho H, et, al. Beta-lactam antibiotics induce a lethal malfunctioning of the bacterial cell wall synthesis machinery. Cell. 2014 Dec 4;159(6):1300-11. DOI:10.1016/j.cell.2014.11.017
[2] Buck RE, et, al. Cefadroxil, a new broad-spectrum cephalosporin. Antimicrob Agents Chemother. 1977 Feb;11(2):324-30. DOI:10.1128/AAC.11.2.324 |
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