| Identification | Back Directory | [Name]
amyrin palmitate | [CAS]
5973-06-8 | [Synonyms]
Balanophorin A
β-Amyrin palmitate
e-Amyrin palpitate
β-Amyrin 3-palmitate
beta-amyrin palmitate
Oleana-12-ene-3β-ol palmitate
Olean-12-en-3β-ol hexadecanoate
5α-Oleana-12-ene-3β-ol hexadecanoate
Olean-12-en-3-ol,3-hexadecanoate, (3b)-
Olean-12-en-3-ol, 3-hexadecanoate, (3β)-
Hexadecanoic acid oleana-12-ene-3β-yl ester | [Molecular Formula]
C46H80O2 | [MOL File]
5973-06-8.mol | [Molecular Weight]
665.14 |
| Chemical Properties | Back Directory | [Boiling point ]
661.4±54.0 °C(Predicted) | [density ]
0.97±0.1 g/cm3(Predicted) | [solubility ]
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | [form ]
Powder | [LogP]
18.579 (est) |
| Hazard Information | Back Directory | [Description]
Beta-Amyrin palmitate may release norepinephrine from newly synthesized pools, and thus, it may activate noradrenergic activity.
Beta-Amyrin palmitate, like mianserin and imipramine, reduces the duration of immobility of mice significantly in a dose-dependent manner (5, 10 and 20 mg kg-1);
(1)Beta-Amyrin palmitate or mianserin elicits a dose-related reduction in locomotor activity of mice and antagonizes locomotor stimulation induced by methamphetamine, imipramine increases locomotor activity and potentiates methamphetamine-induced hyperactivity;
(2)Beta-Amyrin palmitate shows no effect on reserpine-induced hypothermia, whilst mianserin (10 mg kg-1) and imipramine (10 and 20 mg kg-1) antagonizes the reserpine-induced effect;
(3)Beta-amyrin palmitate has similar properties in some respects to mianserin and might possess a sedative action. | [Uses]
β-Amyrin palmitate shows HMG-CoA reductase inhibition[1]. And β-Amyrin palmitate has anti-diabetes mellitus activity[2]. | [target]
LDL | HMG-CoA Reductase | Adrenergic Receptor | [References]
[1] Maurya R, et al. β-Amyrin acetate and β-amyrin palmitate as antidyslipidemic agents from Wrightia tomentosa leaves.?Phytomedicine. 2012;19(8-9):682-685. DOI:10.1016/j.phymed.2012.03.013
[2] Nair SA, et al. Promising anti-diabetes mellitus activity in rats of β-amyrin palmitate isolated from Hemidesmus indicus roots.?Eur J Pharmacol. 2014;734:77-82. DOI:10.1016/j.ejphar.2014.03.050 |
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