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59856-85-8

59856-85-8 Structure

59856-85-8 Structure
IdentificationBack Directory
[Name]

NPD9948
[CAS]

59856-85-8
[Synonyms]

NPD9948
9H-Purine-2,6-diamine, N6-(2-phenylethyl)-
[Molecular Formula]

C13H14N6
[MOL File]

59856-85-8.mol
[Molecular Weight]

254.29
Hazard InformationBack Directory
[Description]

NPD9948 is a competitive MTH1 inhibitor.
[Uses]

NPD9948 is an antitussive agent with antitussive activity in a guinea pig antitussive test. Its half antitussive dose (AtD50) is 14.5 mg/kg and 22.6 mg/kg when injected intraperitoneally and orally, respectively.
[References]

[1] Proteomic profiling of small-molecule inhibitors reveals dispensability of MTH1 for cancer cell survival
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