| Identification | Back Directory | [Name]
DU 717 | [CAS]
59943-31-6 | [Synonyms]
DU 717
7-chloro-3-(4-methyl-1-piperazinyl)-2H-1,2,4-benzothiadiazine 1,1-dioxide
2H-1,2,4-Benzothiadiazine, 7-chloro-3-(4-methyl-1-piperazinyl)-, 1,1-dioxide | [Molecular Formula]
C12H15ClN4O2S | [MDL Number]
MFCD01663192 | [MOL File]
59943-31-6.mol | [Molecular Weight]
314.79 |
| Hazard Information | Back Directory | [Uses]
DU-717 is an antihypertensive agent. | [in vivo]
A gas chromatographic method has been developed which enables accurate determination of a new antihypertensive agent, DU-717, in plasma. Accurate determinations are possible over a concentration range from 10 to 150 ng/mL of DU-717 in plasma at a relative standard deviation of 6.2%. The minimum detectable concentration is 1 ng/mL. Plasma levels of DU-717 in spontaneously hypertensive and normotensive rats following single oral administrations (10 mg/kg) have also been determined[1]. | [storage]
Store at -20°C | [References]
[1] Yamaguchi T, et al. Determination of 7-chloro-3-(4-methyl-1-piperazinyl)-4h-1,2,4-benzothiadiazine-1,1-dioxide (DU-717) in plasma using electron-capture gas chromatography. J Chromatogr. 1978 Oct 11;160(1):181-90. DOI:10.1016/s0021-9673(00)91794-1
[2] R Horie. rats (ALR) and normotensive atherogenic rats (NAR). |
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