59973-80-7

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59973-80-7 Structure

Identification	Back Directory
[Name] SULINDAC SULFONE
[CAS] 59973-80-7
[Synonyms] FGN-1 APTOSYN Prevatec EXISULIND Ccris 7242 Unii-K619iig2R9 SULINDAC SULFONE APTOSYN/EXISULIND Sulindac Impurity B (Z)-Sulindac Sulfone Sulindac USP Related Compound B Sulindac EP Impurity B (Sulindac Sulfone) Sulindac Impurity 2（Sulindac EP Impurity B） Sulindac EP Impurity B (Sulindac USP Related Compound B, Sulindac Sulfone) Sulindac EP Impurity B/ Sulindac Related Compound B ((Z)-Sulindac Sulfone) (Z)-5-FLUORO-2-METHYL-1[P-(METHYLSULFONYL)BENZYLIDENE]INDENE-3-ACETIC ACID cis-5-Fluoro-2-methyl-1-(p-methylsulfonylbenzylidenyl)indene-3-acetic acid 5-Fluoro-2-methyl-1-[(Z)-4-(methylsulfonyl)benzylidene]-1H-indene-3-acetic acid (Z)-5-Fluoro-2-Methyl-1-[[4-(Methylsulfonyl)phenyl]Methylene]-1H-indene-3-acetic Acid 1H-Indene-3-acetic acid, 5-fluoro-2-methyl-1-((4-(methylsulfonyl)phenyl)methylene)-, (1Z)- Sulindac Related Compound B ((Z)-2-{5-fluoro-2-methyl-1-[4-(methylsulfonyl)benzylidene]-1H-inden-3- (1642020)
[Molecular Formula] C20H17FO4S
[MDL Number] MFCD01317811
[MOL File] 59973-80-7.mol
[Molecular Weight] 372.41

Chemical Properties	Back Directory
[Melting point ] 248-250°C
[alpha ] D -62° (c = 1 in CHCl3)
[storage temp. ] Sealed in dry,Room Temperature
[solubility ] DMSO: >25 mg/mL
[form ] solid
[color ] yellow
[Stability:] Hygroscopic

Hazard Information	Back Directory
[Chemical Properties] Yellow Solid
[Uses] An active metabolite of Sulindac. Inducer of apoptosis independent of cyclooxygenase inhibition. Inhibits cell growth by inducing apoptosis.
[Uses] Sulindac Sulfone is an inhibitor of growth and inducer of apoptosis in cancer cell lines.
[Definition] ChEBI: A sulfone metabolite of sulindac that inhibits cell growth by inducing apoptosis independently of cyclooxygenase inhibition. It inhibits the development and induces regression of premalignant adenomatous polyps. Lipoxygenase and Cox-2 inhibitor.

Spectrum Detail	Back Directory
[Spectrum Detail] SULINDAC SULFONE(59973-80-7)¹HNMR

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