| Identification | Back Directory | [Name]
Benzamide, 3-(benzoylamino)-N-(2-ethylphenyl)- | [CAS]
600125-11-9 | [Synonyms]
TASK-1-IN-1
Benzamide, 3-(benzoylamino)-N-(2-ethylphenyl)- | [Molecular Formula]
C22H20N2O2 | [MOL File]
600125-11-9.mol | [Molecular Weight]
344.41 |
| Chemical Properties | Back Directory | [Boiling point ]
400.2±38.0 °C(Predicted) | [density ]
1.230±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
13.12±0.70(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
TASK-1-IN-1 is a potent and selective TASK-1 (Potassium Channel) inhibitor with an IC50 of 148 nM. TASK-1-IN-1 shows a reduced inhibition of TASK-3 channels (IC50 of 1750 nM) and not a significant effect on other K+ channels. TASK-1-IN-1 has anticancer effects. | [References]
[1] Bárbara Arévalo, et al. Selective TASK-1 Inhibitor with a Defined Structure-Activity Relationship Reduces Cancer Cell Proliferation and Viability. J Med Chem. 2022 Nov 24;65(22):15014-15027. DOI:10.1021/acs.jmedchem.1c00378 |
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