| Identification | Back Directory | [Name]
H-ALA-SER-GLY-PRO-LEU-GLY-THR-LEU-ALA-GLU-GLU-LEU-SER-SER-TYR-SER-ARG-ARG-LYS-GLY-GLY-PHE-SER-PHE-ARG-PHE-NH2 | [CAS]
600171-70-8 | [Synonyms]
Rat 26RFa
P550 (MOUSE)
ORPHAN GPCR SP9155 AGONIST P550 (MOUSE)
Orphan GPCR SP9155 agonist P550 (mouse, rat)
ORPHAN G-PROTEIN COUPLED RECEPTOR SP9155 AGONIST PEPTIDE P550 (MOUSE)
Orphan G-Protein Coupled Receptor SP9155 Agonist Peptide P550 (Mouse), P550 (Mouse)
H-ALA-SER-GLY-PRO-LEU-GLY-THR-LEU-ALA-GLU-GLU-LEU-SER-SER-TYR-SER-ARG-ARG-LYS-GLY-GLY-PHE-SER-PHE-ARG-PHE-NH2
Orphan GPCR SP9155 Agonist P550 (Mouse)
Orphan G-Protein Coupled Receptor SP9155 Agonist Peptide P550 (Mouse), P550 (Mouse) | [Molecular Formula]
C126H195N37O37 | [MDL Number]
MFCD08458587 | [MOL File]
600171-70-8.mol | [Molecular Weight]
2820.12 |
| Chemical Properties | Back Directory | [density ]
1.48±0.1 g/cm3(Predicted) | [Sequence]
Ala-Ser-Gly-Pro-Leu-Gly-Thr-Leu-Ala-Glu-Glu-Leu-Ser-Ser-Tyr-Ser-Arg-Arg-Lys-Gly-Gly-Phe-Ser-Phe-Arg-Phe-NH2 |
| Hazard Information | Back Directory | [Uses]
Orphan GPCR SP9155 agonist P550 (mouse, rat) (26RFa (mouse, rat)), a member of the RFamide peptide family with orexigenic effect, is the cognate ligand of the mouse orphan receptor GPR103, also designated SP9155 or AQ27[1][2]. | [in vivo]
26RFa dose-dependently reduces glucose-induced insulin release, inhibits the insulin responses to both arginine and exendin-4 and did not affect glucagon output in rat pancreas[3]. | [References]
[1] Chartrel N, et al. Identification of 26RFa, a hypothalamic neuropeptide of the RFamide peptide family with orexigenic activity. Proc Natl Acad Sci U S A. 2003;100(25):15247-15252. DOI:10.1073/pnas.2434676100
[2] Chartrel N, et al. The Neuropeptide 26RFa (QRFP) and Its Role in the Regulation of Energy Homeostasis: A Mini-Review. Front Neurosci. 2016;10:549. Published 2016 Nov 29. DOI:10.3389/fnins.2016.00549
[3] Egido EM, et al. 26RFa, a novel orexigenic neuropeptide, inhibits insulin secretion in the rat pancreas. Peptides. 2007;28(4):725-730. DOI:10.1016/j.peptides.2006.04.004 |
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