| Identification | Back Directory | [Name]
2-METHYLNICOTINALDEHYDE | [CAS]
60032-57-7 | [Synonyms]
2-METHYLNICOTINALDEHYDE
2-Methylpyridine-3-carbox...
2-Methylpyridine-3-carbaldehyde
2-Methylpyridine-3-carboxaldehyde
2-Methyl-3-Pyridinecarboxaldehyde
3-Pyridinecarboxaldehyde, 2-Methyl-
2-METHYLNICOTINALDEHYDE ISO 9001：2015 REACH | [Molecular Formula]
C7H7NO | [MDL Number]
MFCD08234911 | [MOL File]
60032-57-7.mol | [Molecular Weight]
121.14 |
| Chemical Properties | Back Directory | [Melting point ]
242 °C (decomp) | [Boiling point ]
94 °C(Press: 12 Torr) | [density ]
1.106 g/mL at 25 °C | [refractive index ]
n20/D1.549 | [Fp ]
93℃ | [storage temp. ]
2-8°C, stored under nitrogen | [form ]
liquid | [pka]
4.15±0.10(Predicted) | [color ]
Pale yellow |
| Hazard Information | Back Directory | [Synthesis]
General procedure for the synthesis of 2-methylpyridine-3-carbaldehyde from 2-methylpyridine-3-methanol: A mixture of 3-hydroxymethyl-2-methylpyridine (9.0 g, 73.1 mmol) and manganese(IV) dioxide (28.1 g, 322 mmol) in dichloromethane (100 mL) was heated and refluxed for 48 hours. Upon completion of the reaction, the insoluble material was removed by diatomaceous earth filtration and the filter cake was washed with a solvent mixture of methanol/dichloromethane. Subsequently, the solvent in the filtrate was removed by rotary evaporator to give 2-methylpyridine-3-carboxaldehyde (7.5 g, 85% yield) as an oily product. Its nuclear magnetic resonance hydrogen spectrum (NMR) data were as follows: δ 2.78 (s, 3H), 7.43 (dd, 1H), 8.15 (dd, 1H), 8.66 (dd, 1H). | [References]
[1] Patent: WO2006/106307, 2006, A1. Location in patent: Page/Page column 91
[2] Patent: WO2006/100461, 2006, A1. Location in patent: Page/Page column 83
[3] Chemical and Pharmaceutical Bulletin, 1994, vol. 42, # 9, p. 1841 - 1849
[4] Patent: WO2013/19682, 2013, A1. Location in patent: Page/Page column 101
[5] Patent: WO2013/19626, 2013, A1. Location in patent: Page/Page column 27 |
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