| Identification | Back Directory | [Name]
Ambazone hydrate | [CAS]
6011-12-7 | [Synonyms]
Iversal
Unii-byk4592A3q
Ambazone hydrate
Ambazone-1-hydrate
Ambazone Monohydrate
1,4-Benzoquinone guanylhydrazone thiosemicarbazone hydrate | [Molecular Formula]
C8H13N7OS | [MDL Number]
MFCD00884658 | [MOL File]
6011-12-7.mol | [Molecular Weight]
255.3 |
| Hazard Information | Back Directory | [Originator]
Ambazone,Generic | [Uses]
Ambazone monohydrate is an orally active membrane active antitumor agent. Ambazone monohydrate also shows antibacterial and weak antiviral activities[1]. | [Manufacturing Process]
To a solution of 22.7 g of quinone monoguanylhydrazone nitrate in 250 ml
water is added dropwise hot aqueous solution of 9.1 g thiosemicarbazide, then
is added slowly a solution of 5 ml concentrated nitric acid in 10 ml of water.
The mixture is stirred at 60°C for 1 hour. The product is dissolved in 1-1.2 L
of water at 100°C. The solution is filtered and added to an aqueous
ammonium solution. Blue residue of p-benzoquinone amidinohydrazone
thiosemicarbazone is filtered and dried, melting point 188°C (decomp.). | [Therapeutic Function]
Antiseptic | [References]
[1] G L?ber, et al. Ambazone as a membrane active antitumor drug. Biophys Chem. 1990 Apr;35(2-3):287-300. DOI:10.1016/0301-4622(90)80016-z |
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