60166-85-0

88105-22-0

60166-85-0

General procedure for the synthesis of 5-iodothiophene-2-carboxylic acid (P-2) from methyl 5-iodothiophene-2-carboxylate (P-1): to a 17.5 mL aqueous solution of lithium hydroxide (0.45 g, 11.19 mmol) was added a 35 mL tetrahydrofuran solution of compound P-1 (1.0 g, 3.73 mmol). The reaction mixture was stirred at room temperature for 4 h. The pH was subsequently adjusted to 4 with acid and extracted with ethyl acetate. The organic layer was dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to give 0.86 g (91% yield) of the target compound P-2 as a white solid.1H NMR (400 MHz, CD3OD) δ 7.35 (d, J = 3.8 Hz, 1H), 7.43 (d, J = 3.9 Hz, 1H).