| Identification | Back Directory | [Name]
5-benzoylaminoindole | [CAS]
6019-39-2 | [Synonyms]
OAC2
CS-2128
OAC-2;OAC 2
OAC2?, >98%
5-benzoylaminoindole
N-(1H-Indol-5-yl)benzaMide
Benzamide, N-1H-indol-5-yl- | [Molecular Formula]
C15H12N2O | [MDL Number]
MFCD03055811 | [MOL File]
6019-39-2.mol | [Molecular Weight]
236.27 |
| Chemical Properties | Back Directory | [Melting point ]
165 - 167°C | [Boiling point ]
364.3±15.0 °C(Predicted) | [density ]
1.307±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
13.99±0.43(Predicted) | [color ]
Pale Yellow |
| Hazard Information | Back Directory | [Description]
Octamer-binding transcription factor 4 (Oct4) is a transcription factor which, with Sox2, Klf4, and c-Myc, is involved in the reprogramming of somatic cells to produce pluripotent stem cells. OAC2 is an Oct4-activating compound which activates expression through the Oct4 gene promoter. In cells expressing Oct4 with Sox2, Klf4, and c-Myc, OAC2 (1 μM) enhances reprogramming efficiency by increasing the rate of production of induced pluripotent stem cells (iPSCs) from embryonic fibroblasts. The iPSCs developed using OAC2 retain the capacity for pluripotent differentiation, whether evaluated in vitro or in vivo. | [Uses]
N-(1H-Indol-5-yl)benzamide is a octamer-binding transcription factor 4 activating compound that activated Oct4 and Nanog promoters, which are essential regulators of embryonic stem cell (ESC) pluripotency and key to the reprogramming process. | [storage]
Store at -20°C | [References]
[1] HITOSHI NIWA Austin G S Jun ichi Miyazaki. Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells[J]. Nature genetics, 2000, 24 4: 372-376. DOI: 10.1038/74199
[2] KAZUTOSHI TAKAHASHI. Induction of pluripotent stem cells from adult human fibroblasts by defined factors.[J]. Cell, 2007, 131 5: 861-872. DOI: 10.1016/j.cell.2007.11.019
[3] WENDONG LI. Identification of Oct4-activating compounds that enhance reprogramming efficiency.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2012: 20853-20858. DOI: 10.1073/pnas.1219181110 |
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D&C Chemicals
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+86-21-58447131 |
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www.chemicalbook.com/ShowSupplierProductsList16963/0_EN.htm |
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