| Identification | Back Directory | [Name]
Yuanhuacine | [CAS]
60195-70-2 | [Synonyms]
YHL-14
Odoracin
Nsc261422
NSC 270919
From gnidia
Yuanhuacine
gnidilatidin
Stillingia factor S6
Gnidia B644130K130 origin
(22E,24E)-12β-Benzoyloxy-22,23,24,25-tetradehydrosimplexin
6alpha,7alpha-Epoxy-5beta-hydroxy-9,13,14-ortho-[(2E,4E)-deca-2,4-dien-1-yl]resiniferonol-12beta-yl benzoate
6H-2,8b-Epoxyoxireno[6,7]azuleno[5,4-e]-1,3-benzodioxol-6-one, 10-(benzoyloxy)-3a,3b,3c,4a,5,5a,8a,9,10,10a-decahydro-5,5a-dihydroxy-4a-(hydroxymethyl)-7,9-dimethyl-10a-(1-methylethenyl)-2-(1E,3E)-1,3-nonadien-1-yl-, (2S,3aR,3bS,3cS,4aR,5S,5aS,8aR,8bR,9R,10R,10aS)- | [Molecular Formula]
C37H44O10 | [MDL Number]
MFCD34469585 | [MOL File]
60195-70-2.mol | [Molecular Weight]
648.745 |
| Chemical Properties | Back Directory | [Boiling point ]
765.9±60.0 °C(Predicted) | [density ]
1.35±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
11.00±0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Yuanhuacine (Gnidilatidin), a diterpene from Daphne genkwa, is an effective and highly selective inhibitor of the basal-like 2 (BL2) subtype of TNBC. Yuanhuacine can induce G2/M cell cycle arrest and has broad anti-tumor activity. Yuanhuacine is an orally active DNA damaging agent[1][2][3]. | [in vivo]
Yuanhuacine (0.5-1 mg/kg, oral, once daily, 21 days) inhibits tumor proliferation in mice[1]. | Animal Model: | H1993 cells implanted xenograft mouse model[1] | | Dosage: | 0.5, 1 mg/kg; daily; 21 days | | Administration: | Oral | | Result: | Inhibited tumor growth by 33.4% and 38.8%, respectively, reduced tumor weight, activated AMPK, and inhibited proliferation biomarkers Ki-67 and PCNA in tumor tissues. |
| [References]
[1] Ji In Kang, et al. Anti-Tumor Activity of Yuanhuacine by Regulating AMPK/mTOR Signaling Pathway and Actin Cytoskeleton Organization in Non-Small Cell Lung Cancer Cells. PLoS One. 2015 Dec 11;10(12):e0144368. DOI:10.1371/journal.pone.0144368
[2] Ruowen Zhang, et al. The Chinese herb isolate yuanhuacine (YHL-14) induces G2/M arrest in human cancer cells by up-regulating p21 protein expression through an p53 protein-independent cascade. J Biol Chem. 2014 Mar 7;289(10):6394-403. DOI:10.1074/jbc.M113.513960
[3] Charles S Fermaintt, et al. Yuanhuacine Is a Potent and Selective Inhibitor of the Basal-Like 2 Subtype of Triple Negative Breast Cancer with Immunogenic Potential. Cancers (Basel). 2021 Jun 7;13(11):2834. DOI:10.3390/cancers13112834 |
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