| Identification | Back Directory | [Name]
2-ENEVALPROIC ACID | [CAS]
60218-41-9 | [Synonyms]
2-ene-VPA
delta2,3 Vpe
2-en-valproicacid
2-ENEVALPROIC ACID
delta2-Valproic acid
2-Propyl-2-pentenoate
(E)-2-Ene-valproic acid
E-delta(2)-Valproic acid
2-propylpenten-2-oic Acid
2-PROPYL-2-PENTENOIC ACID
2-N-Propylpent-2-enoic acid
2-Pentenoic acid, 2-propyl-
69827-64-1 (Hydrochloride salt)
(E,Z) 2-Propyl-2-pentenoic Acid | [Molecular Formula]
C8H14O2 | [MDL Number]
MFCD00801107 | [MOL File]
60218-41-9.mol | [Molecular Weight]
142.2 |
| Chemical Properties | Back Directory | [Appearance]
Light-Yellow Solid | [Melting point ]
36 °C | [Boiling point ]
242.9±9.0 °C(Predicted) | [density ]
0.956±0.06 g/cm3(Predicted) | [storage temp. ]
Hygroscopic, -20?C Freezer, Under Inert Atmosphere | [solubility ]
DMF: 15 mg/ml; DMSO: 20 mg/ml; Ethanol: 30 mg/ml; PBS (pH 7.2): 1 mg/ml | [form ]
neat | [pka]
5.03±0.36(Predicted) | [BRN ]
1721109 | [Stability:]
Hygroscopic, Light, Temperature and Moisture Sensitive | [Major Application]
pharmaceutical | [InChI]
1S/C8H14O2/c1-3-5-7(6-4-2)8(9)10/h5H,3-4,6H2,1-2H3,(H,9,10)/b7-5+ | [InChIKey]
ZKNJEOBYOLUGKJ-FNORWQNLSA-N | [SMILES]
CC/C=C(CCC)/C(O)=O |
| Hazard Information | Back Directory | [Chemical Properties]
Light-Yellow Solid | [Uses]
A metabolite of Valproic Acid | [Description]
(E,Z)-2-propyl-2-Pentenoic acid is a bioactive metabolite of valproic acid that exhibits the same profile and potency of anticonvulsant activity in animal models as its parent compound without any observed teratogenicity and hepatotoxicity. | [References]
[1] A W RETTENMEIER. Metabolic fate of valproic acid in the rhesus monkey. Formation of a toxic metabolite, 2-n-propyl-4-pentenoic acid.[J]. Drug Metabolism and Disposition, 1986, 14 4: 443-453.
[2] WOLFGANG L?SCHER. Trans-2-en-valproate: reevaluation of its anticonvulsant efficacy in standardized seizure models in mice, rats and dogs[J]. Epilepsy Research, 1991, 9 3: Pages 195-210. DOI: 10.1016/0920-1211(91)90053-i |
| Safety Data | Back Directory | [Hazard Codes ]
T | [Risk Statements ]
25 | [Safety Statements ]
45 | [RIDADR ]
UN 2811 6.1 / PGIII | [WGK Germany ]
3 | [Storage Class]
6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | [Hazard Classifications]
Acute Tox. 3 Oral |
|
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BOC Sciences
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https://www.bocsci.com |
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Sigma-Aldrich
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021-61415566 800-8193336 |
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https://www.sigmaaldrich.cn |
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