| Identification | Back Directory | [Name]
Calcium folinatc | [CAS]
6035-45-6 | [Synonyms]
Folaren
Foliben
Folidan
NSC-3590
Calcium folinatc
Folinic acid calcium salt
Leucovorin calcium pentahydrate
FOLINIC ACID(SEE CALCIUM FOLINATE)
CALCIUM FOLINATE(FOLINIC ACID)(RG)
FOLINIC ACID CALCIUM CELL CULTURE TESTED
Folinic acid, calcium salt pentahydrate,95-105% %
Folinic acid, calcium salt pentahydrate, 95.0-105.0%
CalciuM folinate, pentahydrate / 5-ForMyl-5,6,7,8-tetrahydrofolic acid, calciuM salt / Leucovorin
Calcium (2S)-2-[[4-[(2-amino-5-formyl-4-oxo-1,6,7,8-tetrahydropteridin-6-yl)methylamino]benzoyl]amino]pentanedioate
N-[4-[[(2-AMino-5-forMyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)Methyl]aMino]benzoyl]-L-glutaMic Acid CalciuM Salt Pentahydrate
N-[4-[[(2-amino-5-formyl-3,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid, calcium salt, hydrate (1:1:5) | [Molecular Formula]
C20H21CaN7O7 | [MDL Number]
MFCD00006704 | [MOL File]
6035-45-6.mol | [Molecular Weight]
511.5 |
| Chemical Properties | Back Directory | [Appearance]
yellowish-white to yellow powder | [Melting point ]
240-250°C | [alpha ]
D21 +14.9° (c = 1 in water) | [storage temp. ]
Store at RT. | [solubility ]
insoluble in DMSO; insoluble in EtOH; ≥15.04 mg/mL in H2O with gentle warming | [form ]
powder
| [color ]
Yellow-white to yellow | [InChIKey]
QUCDGUZWVVGQDO-WJYQJPTCNA-N | [SMILES]
C(N1C(CNC2NC(N)=NC(=O)C1=2)CNC1C=CC(C(=O)N[C@H](C(=O)O)CCC(=O)O)=CC=1)=O.[Ca].O |&1:22,r| |
| Hazard Information | Back Directory | [Chemical Properties]
yellowish-white to yellow powder | [Uses]
An intermediate product of the metabolism of Folic Acid. This compound is a mixture of diastereomers. | [Uses]
Antianemic | [Brand name]
Wellcovorin (GlaxoSmithKline). | [Biological Activity]
human lymphoid cell lines were studied for leucovorin requirements to protect from methotrexate (mtx)-induced growth suppression. over a 72h continuous exposure leucovorin provided better protection to the cell lines laz-007 and raji than to the cell line | [in vivo]
Folinic acid (7.0 mg/kg; intraperitoneal injection; every second day; for 3 weeks; Balb/c young growing male mice) treatment following methotrexate (MTX) administration appears to reverse this growth inhibition (Chronic administration of MTX induces suppression of skeletal growth in mice)[2]. | Animal Model: | 24 Balb/c young growing male mice aged 3 weeks (11.88 ± 0.25 g)[2] | | Dosage: | 7.0 mg/kg | | Administration: | Intraperitoneal injection; every second day; for 3 weeks | | Result: | Following methotrexate (MTX) administration appears to reverse this growth inhibition.
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| [IC 50]
Human Endogenous Metabolite |
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