| Identification | Back Directory | [Name]
6,7,8-TRIMETHOXYCOUMARIN | [CAS]
6035-49-0 | [Synonyms]
DIMETHYLFRAXETIN
Di-O-Methylfraxetin
O,O-DIMETHYLFRAXETIN
DIMETHYLFRAXETIN, O,O-
Dimethylfraxetin, >99%
Fraxetin dimethyl ether
6,7,8-TRIMETHOXYCOUMARIN
DIMETHYLFRAXETIN, O,O-(P)
DIMETHYLFRAXETIN, O,O-(RG)
CouMarin, 6,7,8-triMethoxy-
6,7,8-TriMethoxy-2H-chroMen-2-one
Fraxetin dimethylether (6,7,8-OMe)
2H-1-Benzopyran-2-one,6,7,8-triMethoxy
6,7,8-Trimethoxy-2H-1-benzopyran-2-one
Dimethylfraxetin
6,7,8-Trimethoxycoumarin
6,7,8-TRIMETHOXYCOUMARIN ISO 9001：2015 REACH | [EINECS(EC#)]
200-485-9 | [Molecular Formula]
C12H12O5 | [MDL Number]
MFCD00145039 | [MOL File]
6035-49-0.mol | [Molecular Weight]
236.22 |
| Chemical Properties | Back Directory | [Melting point ]
104-105°C | [Boiling point ]
338.68°C (rough estimate) | [density ]
1.249 | [refractive index ]
1.5140 (estimate) | [storage temp. ]
Sealed in dry,2-8°C | [solubility ]
DMSO : 125 mg/mL (529.17 mM; Need ultrasonic and warming) | [form ]
Cryst. | [color ]
White to yellow | [biological source]
plant | [Major Application]
metabolomics
vitamins, nutraceuticals, and natural products | [InChI]
InChI=1S/C12H12O5/c1-14-8-6-7-4-5-9(13)17-10(7)12(16-3)11(8)15-2/h4-6H,1-3H3 | [InChIKey]
RAYQKHLZHPFYEJ-UHFFFAOYSA-N | [SMILES]
C1(=O)OC2=C(OC)C(OC)=C(OC)C=C2C=C1 |
| Hazard Information | Back Directory | [Chemical Properties]
White crystals, soluble in methanol, ethanol, DMSO and other organic solvents, derived from Fraxinuschinensis Roxb. | [Uses]
Dimethylfraxetin has a bactericidal, anti-inflammatory, anti-radiation damage, and immune-enhancing effects. | [Definition]
ChEBI: 6,7,8-trimethoxy-1-benzopyran-2-one is a member of coumarins. | [Biological Activity]
Dimethylfraxetin is a Carbonic anhydrase inhibitor with a Ki of 0.0097 μM. | [in vitro]
At CA I there is one stand out compound being Dimethylfraxetin (compound 17), a nanomolar CA I inhibitor. This trimethoxy coumarin is the most potent of any of the NP coumarins across the six CA isozymes of the present study . | [target]
Ki: 0.0097 μM (Carbonic anhydrase) |
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