| Identification | Back Directory | [Name]
CBRCULCCRGSSLB-UHFFFAOYSA-N | [CAS]
603987-59-3 | [Synonyms]
Ty-51469
TY 51469,TY51469
CBRCULCCRGSSLB-UHFFFAOYSA-N | [Molecular Formula]
C20H15FN2O6S4 | [MDL Number]
MFCD16628177 | [MOL File]
603987-59-3.mol | [Molecular Weight]
526.6 |
| Chemical Properties | Back Directory | [Melting point ]
257-258 °C | [Boiling point ]
818.8±75.0 °C(Predicted) | [density ]
1.620±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
3.30±0.10(Predicted) | [color ]
Off-white to light brown | [InChIKey]
CBRCULCCRGSSLB-UHFFFAOYSA-N | [SMILES]
FC1=CC2=C(C=C1)SC(S(NC3=CC=C(C=C3S(C)(=O)=O)C4=NC(C(O)=O)=CS4)(=O)=O)=C2C |
| Hazard Information | Back Directory | [Uses]
TY-51469 is a chymase inhibitor with IC50s for simian and human chymases of 0.4 and 7.0 nM, respectively. | [Biological Activity]
TY-51469 is a potent and selective chymase inhibitor th at prevents development and progression of non-alcoholic steatohepatitis in rats. TY-51469 inhibits activation of intestinal MMP-9 and prevents intestinal damage in indomethacin-induced small intestinal damage in rats. Also TY-51469 might protect against pancreatic islet disorganization. | [in vivo]
TY-51469 shows 100% stability in rat plasma at 40°C for as long as 1 hour[1]. TY-51469 suppresses the accumulation of neutrophils in the lung and reduces silica-induced pulmonary fibrosis in mice[2]. | [References]
[1] Takato H, et al. The specific chymase inhibitor TY-51469 suppresses the accumulation of neutrophils in the lung and reduces silica-induced pulmonary fibrosis in mice. Expert Opinion on Therapeutic Targets Volume 15, 2011 - Issue 4. |
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| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
|