| Identification | Back Directory | [Name]
NEUROTENSIN (8-13) | [CAS]
60482-95-3 | [Synonyms]
RRPYIL
NEUROTENSIN (8-13)
Neurotensin(8-13)【ox】
Neurotensin(8-13)(3TFA)
ARG-ARG-PRO-TYR-ILE-LEU
NEUROTENSIN, FRAGMENT 8-13
H-ARG-ARG-PRO-TYR-ILE-LEU-OH
neurotensin fragment 8-13 acetate
ARG-ARG-PRO-TYR-ILE-LEU ACETATE SALT
AC-ARG-ARG-PRO-TYR-ILE-LEU: AC-RRPYIL
L-Arg-L-Arg-L-Pro-L-Tyr-L-Ile-L-Leu-OH
NEUROTENSIN FRAGMENT 8-13 ACETATE SALT
Neurotensin (8-13) H-Arg-Arg-Pro-Tyr-Ile-Leu-OH
Neurotensin Fragment 8-13 acetate salt >=97% (HPLC)
L-Leucine, L-arginyl-L-arginyl-L-prolyl-L-tyrosyl-L-isoleucyl- | [Molecular Formula]
C38H64N12O8 | [MDL Number]
MFCD00076686 | [MOL File]
60482-95-3.mol | [Molecular Weight]
816.99 |
| Chemical Properties | Back Directory | [density ]
1.40±0.1 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Sealed in dry,Store in freezer, under -20°C | [form ]
Solid | [pka]
3.41±0.10(Predicted) | [color ]
White to off-white | [Water Solubility ]
Water: 50 mg/mL (61.20 mM) | [Sequence]
H-Arg-Arg-Pro-Tyr-Ile-Leu-OH |
| Hazard Information | Back Directory | [Uses]
Neurotensin (8-13) is an active fragment of Neurotensin. Neurotensin(8-13) results in a decrease in cell-surface NT1 receptors (NTR1) density. | [Biological Activity]
Neurotensin (8-13) is the active fragment of neurotensin, Neurotensin (8-13) reduces cell surface NT1 receptor (NTR1) density. | [in vitro]
Receptor internalization induced by Neurotensin(8-13) results in a decrease in cell-surface NT1 receptors (NTR1) density. The receptor downregulation in response to high extracellular concentrations of the peptide has been described for Neurotensin (NT ) in HT-29 cells and in rat primary cultured neurons. Reappearance of the receptors on the cell surface is also different. | [target]
| [IC 50]
NTR1 | [storage]
Store at -20°C | [References]
[1] García-Garayoa E, et al. Preclinical evaluation of a new, stabilized neurotensin(8--13) pseudopeptide radiolabeled with (99m)tc. J Nucl Med. 2002 Mar;43(3):374-83. PMID:11884498 |
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