| Identification | Back Directory | [Name]
2-CHLORO-5-NITRONICOTINAMIDE | [CAS]
60524-15-4 | [Synonyms]
2-CHLORO-5-NITRONICOTINAMIDE
2-Chloro-5-nitro-3-Pyridinecarboxamide
3-Pyridinecarboxamide, 2-chloro-5-nitro- | [Molecular Formula]
C6H4ClN3O3 | [MDL Number]
MFCD01860226 | [MOL File]
60524-15-4.mol | [Molecular Weight]
201.57 |
| Hazard Information | Back Directory | [Synthesis Reference(s)]
Journal of Medicinal Chemistry, 20, p. 129, 1977 DOI: 10.1021/jm00211a027 | [Synthesis]
Compound 21 (8.3 g, 0.04 mol) was added to thionyl chloride (80 mL) and heated to reflux for 3 hours. Upon completion of the reaction, excess thionyl chloride was removed by distillation under reduced pressure. Acetone (240 mL) was added to the residue with stirring at 25 °C and ammonia was added slowly and dropwise, the reaction lasted for 10 min. The reaction mixture was concentrated to one-fourth of the original volume and the concentrate was poured into 200 g of crushed ice, precipitating a yellow solid. The solid was collected by filtration to give 4.5 g of the target product 2-chloro-5-nitro-3-pyridine carboxamide in 54.2% yield. The melting point of the product was 177.3-178.2 °C. | [References]
[1] Russian Chemical Bulletin, 2005, vol. 54, # 8, p. 1907 - 1914
[2] Patent: EP2366691, 2011, A1. Location in patent: Page/Page column 10
[3] Antimicrobial Agents and Chemotherapy, 2014, vol. 58, # 1, p. 55 - 60 |
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