| Identification | Back Directory | [Name]
HOMOPTEROCARPIN | [CAS]
606-91-7 | [Synonyms]
3,9-Dimethoxypterocarpan
(6aR)-6a,11aα-Dihydro-3,9-dimethoxy-6H-benzofuro[3,2-c][1]benzopyran
(6aR)-6aα,11aα-Dihydro-3,9-dimethoxy-6H-benzofuro[3,2-c][1]benzopyran
6H-Benzofuro[3,2-c][1]benzopyran, 6a,11a-dihydro-3,9-dimethoxy-, (6aR,11aR)- | [Molecular Formula]
C17H16O4 | [MOL File]
606-91-7.mol | [Molecular Weight]
284.31 |
| Hazard Information | Back Directory | [Description]
Homopterocarpin and Pterocarpus extract offer gastroprotection against indomethacin-
induced ulcer by antioxidative mechanism and the modulation of gastric homeostasis, homopterocarpin may be responsible for, or contribute to the antiulcerogenic property of P. erinaceus.
Homopterocarpin can inhibit (lower concentration) or kill (higher concntration) human^s liver cancer cells under the cultured condition, they have anticancer activity.
3. Homopterocarpin can contribute to the hepatoprotective and antioxidant potentials of P. erinaceus extract in acetaminophen-provoked hepatotoxicity.
4. (-)-Homopterocarpin has active insect antifeedant against both S. litura and R. speratus.
5. (+)-Homopterocarpin has antimitotic effect. | [Uses]
Homopterocarpin is an isoflavonoid that can be isolated from Pterocarpus erinaceus. Homopterocarpin has hepatoprotective and antioxidant properties. Homopterocarpin is a competitive reversible inhibitor of human monoamine oxidase-B with an IC50 and a Ki of 0.72 and 0.21 μM for hMAO-B, respectively. Homopterocarpin can be used for the research of liver injury and oxidative stress[1][2]. | [Definition]
ChEBI: (6aR,11aR)-3,9-dimethoxy-6a,11a-dihydro-6H-benzofuro[3,2-c][1]benzopyran is a member of pterocarpans. | [target]
Antifection | [References]
[1] Akinmoladun AC, et al. Effect of homopterocarpin, an isoflavonoid from Pterocarpus erinaceus, on indices of liver injury and oxidative stress in acetaminophen-provoked hepatotoxicity. J Basic Clin Physiol Pharmacol. 2015 Nov;26(6):555-62. DOI:10.1515/jbcpp-2014-0095
[2] Oh JM, et al. Medicarpin and Homopterocarpin Isolated from Canavalia lineata as Potent and Competitive Reversible Inhibitors of Human Monoamine Oxidase-B. Molecules. 2022 Dec 28;28(1):258. DOI:10.3390/molecules28010258 |
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