| Identification | Back Directory | [Name]
1-(4-methoxy)phenyl-3-methyl-5-pyrazolone | [CAS]
60798-06-3 | [Synonyms]
1-(4-methoxy)phenyl-3-methyl-5-pyrazolone
1-(4-methoxyphenyl)-3-methyl-2-pyrazolin-5-one
1-(4-methoxyphenyl)-3-methyl-1H-pyrazol-5(4H)-one
1-(4-methoxyphenyl)-3-methyl-4,5-dihydro-1H-pyrazol-5-one
3H-Pyrazol-3-one, 2,4-dihydro-2-(4-methoxyphenyl)-5-methyl- | [Molecular Formula]
C11H12N2O2 | [MDL Number]
MFCD01361012 | [MOL File]
60798-06-3.mol | [Molecular Weight]
204.23 |
| Chemical Properties | Back Directory | [Melting point ]
130 °C(Solv: ethanol (64-17-5)) | [Boiling point ]
392.5±25.0 °C(Predicted) | [density ]
1.19±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
2.79±0.50(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
1-(4-Methoxyphenyl)-3-methyl-1H-pyrazol-5(4H)-one (Compound 2) has antiprion activity in ScN2a and F3 cells with IC50 values of 13 nM and 25 nM, respectively[1]. | [References]
[1] Kimata A, et al. New series of antiprion compounds: pyrazolone derivatives have the potent activity of inhibiting protease-resistant prion protein accumulation. J Med Chem. 2007 Oct 18;50(21):5053-6. DOI:10.1021/jm070688r |
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