| Identification | Back Directory | [Name]
ARECOLINE HYDROCHLORIDE | [CAS]
61-94-9 | [Synonyms]
RARECHEM AX KI 5022
ARECOLINE HYDROCHLORIDE
methyl 1-methyl-3,6-dihydro-2H-pyridine-5-carboxylate hydrochloride
nicotinicacid,1,2,5,6-tetrahydro-1-methyl-,methylester,hydrochloride
methyl 1-methyl-1,2,5,6-tetrahydropyridine-3-carboxylate hydrochloride
3-pyridinecarboxylicacid,1,2,5,6-tetrahydro-1-methyl-,methylester,hydroc
3-Pyridinecarboxylic acid, 1,2,5,6-tetrahydro-1-Methyl-, Methyl ester, hydrochloride | [EINECS(EC#)]
200-523-6 | [Molecular Formula]
C8H14ClNO2 | [MDL Number]
MFCD00054321 | [MOL File]
61-94-9.mol | [Molecular Weight]
191.66 |
| Hazard Information | Back Directory | [Uses]
Arecoline hydrochloride, a naturally occurring psychoactive alkaloid, is a partial agonist of nicotinic and muscarinic acetylcholine receptor. Arecoline hydrochloride exhibits stimulation, alertness, anxiolysis and anti-parasitic effects. Arecoline hydrochloride also can induce oxidative stress[1][2][3][4]. | [Safety Profile]
Poison by intraperitoneal andintravenous routes. Questionable carcinogen withexperimental carcinogenic data. Whenheated to decomposition it emits very toxic fumes of NOxand HCl. | [References]
[1] Thangjam GS, et, al. Regulation of oxidative-stress responsive genes by arecoline in human keratinocytes. J Periodontal Res. 2009 Oct;44(5):673-82. DOI:10.1111/j.1600-0765.2008.01176.x
[2] Liu YJ, et, al. The pharmacology, toxicology and potential applications of arecoline: a review. Pharm Biol. 2016 Nov;54(11):2753-2760. DOI:10.3109/13880209.2016.1160251
[3] Volgin AD, et, al. DARK Classics in Chemical Neuroscience: Arecoline. ACS Chem Neurosci. 2019 May 15;10(5):2176-2185. DOI:10.1021/acschemneuro.8b00711
[4] Kuo TM, et, al. Arecoline induces TNF-alpha production and Zonula Occludens-1 redistribution in mouse Sertoli TM4 cells. J Biomed Sci. 2014 Sep 9;21(1):93. DOI:10.1186/s12929-014-0093-z |
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Leancare Ltd.
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