| Identification | Back Directory | [Name]
ORM-12741 | [CAS]
610782-82-6 | [Synonyms]
ORM10921
ORM-10921
ORM-12741
ORM 10921
ORM 10921,ORM10921
2H-Benzofuro[2,3-a]quinolizine, 1,3,4,6,7,12b-hexahydro-1-(methoxymethyl)-1-methyl-, (1S,12bS)- | [Molecular Formula]
C18H23NO2 | [MOL File]
610782-82-6.mol | [Molecular Weight]
285.38 |
| Chemical Properties | Back Directory | [Boiling point ]
384.0±32.0 °C(Predicted) | [density ]
1.16±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
7.70±0.40(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
ORM-10921 free base is a selective α-2C adrenergic receptor antagonist with a Ki of 1.4 nM. ORM-10921 free base displays potent antidepressant and antipsychotic-like effects[1]. | [IC 50]
Alpha-2C adrenergic receptor: 1.4 nM (Ki) | [References]
[1] Jukka Sallinen, et al. Pharmacological characterisation of a structurally novel α2C-adrenoceptor antagonist ORM-10921 and its effects in neuropsychiatric models. Basic Clin Pharmacol Toxicol. 2013 Oct;113(4):239-49. DOI:10.1111/bcpt.12090 |
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