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612847-42-4

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612847-42-4 Structure

612847-42-4 Structure
IdentificationBack Directory
[Name]

Merck-22-6
[CAS]

612847-42-4
[Synonyms]

Merck-22-6
Merck-22-6 >=95%
Merck-22-6 (KRC380)
6-Quinoxalinecarboxamide, N-[2-(diethylamino)ethyl]-3-[4-[[4-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]methyl]phenyl]-2-phenyl-
N-(2-(diethylamino)ethyl)-3-(4-((4-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)methyl)phenyl)-2-phenylquinoxaline-6-carboxamide
[Molecular Formula]

C40H43N7O2
[MDL Number]

MFCD21608460
[MOL File]

612847-42-4.mol
[Molecular Weight]

653.82
Chemical PropertiesBack Directory
[form ]

Solid
[color ]

Off-white to light yellow
Hazard InformationBack Directory
[Description]

Merck-22-6 is an allosteric dual Akt1, Akt2 inhibitor.
[Uses]

Akt1/Akt2-IN-2 (compound 7) is an allosteric dual Akt1 and Akt2 inhibitor (IC50=138 nM and 212 nM, respectively). Akt1/Akt2-IN-2 increases activity of caspase-3, and inhibits viability of a number of tumor cells[1].
[IC 50]

Akt1: 138 nM (IC50); Akt2: 212 nM (IC50); Akt3: 7.2 mM (IC50); Caspase-3
[References]

[1] Zhao Z, et al. Development of potent, allosteric dual Akt1 and Akt2 inhibitors with improved physical properties and cell activity. Bioorg Med Chem Lett. 2008 Jan 1;18(1):49-53. DOI:10.1016/j.bmcl.2007.11.015
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