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MB327 is a bipyridine nonoxime compound that restores neuromuscular function. MB327 restores the activity of nicotinamide acetylcholine receptors (nAChRs) for carbachol desensitization in a typical type II PAM manner. MB327 can neutralize nerve agent poisoning[1][2]. | [References]
[1] Niessen K V, et al. In vitro pharmacological characterization of the bispyridinium non-oxime compound MB327 and its 2-and 3-regioisomers[J]. Toxicology Letters, 2018, 293: 190-197. DOI:10.1016/j.toxlet.2017.10.009
[2] Seeger T, et al. Restoration of soman-blocked neuromuscular transmission in human and rat muscle by the bispyridinium non-oxime MB327 in vitro[J]. Toxicology, 2012, 294(2-3): 80-84. DOI:10.1016/j.tox.2012.02.002 |
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