| Identification | Back Directory | [Name]
TYR-D-ALA-GLY-PHE-MET | [CAS]
61370-87-4 | [Synonyms]
DAMET
Dalmee
ala(2)-enkephalin-me
TYR-D-ALA-GLY-PHE-MET
Met-enkephalin, ala(2)-
enkephalin-Met, Ala(2)-
L-TYR-D-ALA-GLY-PHE-MET
(D-ALA2) MET-ENKEPHALIN
[D-ALA2,MET5]-ENKEPHALIN
a,a-D-Trehaloseanhydrous
ENKEPHALIN, MET- (D-ALA2)
(D-ALA2-OL)-MET ENKEPHALIN
H-TYR-D-ALA-GLY-PHE-MET-OH
L-TYR-D-ALA-GLY-PHE-MET-OL CH3COOH
L-Methionine, L-tyrosyl-D-alanylglycyl-L-phenylalanyl- | [Molecular Formula]
C28H37N5O7S | [MDL Number]
MFCD00076417 | [MOL File]
61370-87-4.mol | [Molecular Weight]
587.69 |
| Hazard Information | Back Directory | [Description]
Enkephalin-met, ala(2)- is a synthetic analog of methionine enkephalin. | [Uses]
[D-Ala2]-Met-Enkephalin, an opioid peptide, is a potent opioid agonist. [D-Ala2]-Met-Enkephalin inhibits ACh-induced and suckling-induced oxytocin (OT) release[1][2]. | [in vivo]
[D-Ala2]-Met-Enkephalin (0.01-1μg; ICV; once) inhibits suckling-induced oxytocin (OT) release in lactating mice[1]. | Animal Model: | Lactating rats[1] | | Dosage: | 0.01, 0.1 and 1 μg | | Administration: | Intracerebroventrical injection | | Result: | Inhibited ACh-induced and suckling-induced OT release. |
| [References]
[1] Haldar J, et, al. Morphine, β-endorphin and [D-Ala2] Met-enkephalin inhibit oxytocin release by acetylcholine and suckling. 1982 Jul–Aug;3(4):663-8.
[2] Godoy AM, et, al. Modulation of the escape response by [d-Ala2]Met-enkephalin in the crab Chasmagnathus. 1995 Mar;50(3):445-51. |
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