| Identification | Back Directory | [Name]
1-[2,4-Dihydroxy-3,5-bis[(2-hydroxyphenyl)methyl]-6-methoxyphenyl]-3-phenyl-1-propanone | [CAS]
61463-04-5 | [Synonyms]
Diuvaretin
1-[2,4-Dihydroxy-3,5-bis[(2-hydroxyphenyl)methyl]-6-methoxyphenyl]-3-phenyl-1-propanone
1-Propanone, 1-[2,4-dihydroxy-3,5-bis[(2-hydroxyphenyl)methyl]-6-methoxyphenyl]-3-phenyl- | [Molecular Formula]
C30H28O6 | [MOL File]
61463-04-5.mol | [Molecular Weight]
484.54 |
| Chemical Properties | Back Directory | [storage temp. ]
-20°C | [solubility ]
water: slightly soluble | [form ]
solid | [biological source]
plant | [Water Solubility ]
water: slightly soluble | [Major Application]
metabolomics
vitamins, nutraceuticals, and natural products | [InChI]
1S/C30H28O6/c1-36-30-23(18-21-12-6-8-14-25(21)32)28(34)22(17-20-11-5-7-13-24(20)31)29(35)27(30)26(33)16-15-19-9-3-2-4-10-19/h2-14,31-32,34-35H,15-18H2,1H3 | [InChIKey]
KDEMELRYKGOXDL-UHFFFAOYSA-N | [SMILES]
O(C)c1c(c(c(c(c1C(=O)CCc4ccccc4)O)Cc3c(cccc3)O)O)Cc2c(cccc2)O |
| Hazard Information | Back Directory | [Uses]
It is a natural product derived from plant source th at finds application in compound screening libraries, metabolomics, phytochemical, and pharmaceutical research. | [Definition]
ChEBI: Diuvaretin is a member of the class of dihydrochalcones that is dihydrochalcone substituted by 2-hydroxybenzyl groups at positions 3 and 5, hydroxy groups at positions 2 and 4 and a methoxy group at position 6. Isolated from the roots of Uvaria acuminata and Uvaria chamae, it exhibits cytotoxicity towards human promyelocytic leukemia HL-60 cells. It has a role as a metabolite, an antineoplastic agent and an antimalarial. It is a member of dihydrochalcones, a member of resorcinols and a monomethoxybenzene. | [Biological Activity]
Diuvaretin exhibits cytotoxicity towards human promyelocytic leukemia HL-60 cells. It has a role as a metabolitean antineoplastic agent and an antimalarial. ''Diuvaretin inhibits NF-kB activationhindering inflammation and cancer. It also suppresses tumor cell proliferationinduces apoptosisand diminishes tumor growth and angiogenesis in mouse cancer models. |
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| Company Name: |
Merck KGaA
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| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
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