| Identification | Back Directory | [Name]
3,4-DIHYDROXY HYDROCINNAMIC ACID (L-ASPARTIC ACID DIBENZYL ESTER) AMIDE | [CAS]
615264-62-5 | [Synonyms]
CAY10485
CAY10485,CAY-10485
SNEUAEKNRYBOTP-QFIPXVFZSA-N
3,4-DIHYDROXY HYDROCINNAMIC ACID (L-ASPARTIC ACID DIBENZYL ESTER) AMIDE
N-[3-(3,4-DIHYDROXYPHENYL)-1-OXOPROPYL]-L-ASPARTIC ACID, BIS(PHENYLMETHYL) ESTER
L-Aspartic acid, N-[3-(3,4-dihydroxyphenyl)-1-oxopropyl]-, 1,4-bis(phenylmethyl) ester | [Molecular Formula]
C27H27NO7 | [MDL Number]
MFCD08062181 | [MOL File]
615264-62-5.mol | [Molecular Weight]
477.51 |
| Chemical Properties | Back Directory | [Boiling point ]
727.6±60.0 °C(Predicted) | [density ]
1.292±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 20 mg/ml; DMSO: 20 mg/ml; Ethanol: 20 mg/ml; Ethanol:PBS (pH 7.2)(1:3): .25 mg/ml | [form ]
A crystalline solid | [pka]
9.77±0.10(Predicted) |
| Hazard Information | Back Directory | [Uses]
LDL-IN-4 (Compound 2) inhibits human acyl-CoA:cholesterol acyltransferase-1 and -2 activities. LDL-IN-4 inhibits copper-mediated low density lipoprotein (LDL) oxidation, with an IC50 of 3 μM. LDL-IN-4 has anti-atherosclerotic biological activity[1]. | [References]
[1] Lee S, et al. Synthesis of cinnamic acid derivatives and their inhibitory effects on LDL-oxidation, acyl-CoA:cholesterol acyltransferase-1 and -2 activity, and decrease of HDL-particle size. Bioorg Med Chem Lett. 2004 Sep 20;14(18):4677-81. DOI:10.1016/j.bmcl.2004.06.101 |
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