| Identification | Back Directory | [Name]
DC4SMe | [CAS]
615538-47-1 | [Synonyms]
DC4SMe
DC-4SMe,DC4SMe
1H-Indole-2-carboxamide, N-[2-[[(1S)-1-(chloromethyl)-1,2-dihydro-5-(phosphonooxy)-3H-benz[e]indol-3-yl]carbonyl]-1H-indol-5-yl]-5-[[3-(methyldithio)-1-oxopropyl]amino]- | [Molecular Formula]
C35H31ClN5O7PS2 | [MDL Number]
MFCD34469687 | [MOL File]
615538-47-1.mol | [Molecular Weight]
764.2 |
| Hazard Information | Back Directory | [Uses]
DC4SMe, a phosphate proagent of cytotoxic DNA alkylator DC4, can be used in the synthesis of antibody-drug conjugate (ADC). DC4SMe exhibits IC50s of 1.9 nM, 2.9 nM, and 1.8 nM for Ramos, Namalwa, and HL60/s cancer cells, respectively. DC4SMe can be used for the targeted treatment of cancer[1]. | [IC 50]
Duocarmycins | [References]
[1] Zhao RY, et al. Synthesis and biological evaluation of antibody conjugates of phosphate prodrugs of cytotoxic DNA alkylators for the targeted treatment of cancer. J Med Chem. 2012 Jan 26;55(2):766-82. DOI:10.1021/jm201284m |
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