| Identification | Back Directory | [Name]
L-Threoninamide, 5-oxo-L-prolyl-L-leucyl-L-asparaginyl-L-phenylalanyl-L-threonyl-L-prolyl-L-asparaginyl-L-tryptophylglycyl- | [CAS]
61627-67-6 | [Synonyms]
L-Threoninamide, 5-oxo-L-prolyl-L-leucyl-L-asparaginyl-L-phenylalanyl-L-threonyl-L-prolyl-L-asparaginyl-L-tryptophylglycyl- | [Molecular Formula]
C54H74N14O15 | [MOL File]
61627-67-6.mol | [Molecular Weight]
1159.25 |
| Hazard Information | Back Directory | [Uses]
Adipokinetic hormone I (Locusta migratoria) (Lom-AKH-I) is a insect adipokinetic hormone (AKH), enhances fat body cAMP levels in vitro. Insect adipokinetic hormones (AKHs) controls flight-directed mobilization of carbohydrate and lipid from fat body stores, which depends on AKH receptor(s) coupling to cAMP formation and glycogen phosphorylase activation via the stimulatory guanine nucleotide-binding protein (Gs)[1][3]. | [in vivo]
Adipokinetic hormone I (Locusta migratoria) (1 pmol in 10 μL of 10% methanol; injection) plays its own biol. role in the overall syndrome of insect flight, with different half-lives of 51 min and 35 min during rest and flight, respectively[1].
| [References]
[1] Oudejans RC, et al. Locust adipokinetic hormones: carrier-independent transport and differential inactivation at physiological concentrations during rest and flight. Proc Natl Acad Sci U S A. 1996 Aug 6;93(16):8654-9. DOI:10.1073/pnas.93.16.8654
[2] Gautam UK, et al. Adipokinetic hormone promotes infection with entomopathogenic fungus Isaria fumosorosea in the cockroach Periplaneta americana. Comp Biochem Physiol C Toxicol Pharmacol. 2020 Mar;229:108677. DOI:10.1016/j.cbpc.2019.108677
[3] Vroemen SF, et al. Stimulation of glycogenolysis by three locust adipokinetic hormones involves Gs and cAMP. Mol Cell Endocrinol. 1995 Feb;107(2):165-71. DOI:10.1016/0303-7207(94)03438-y
[4] Goldsworthy, et al. The relative potencies of two known locust adipokinetic hormones. 1986;32(1):95-101. |
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