| Identification | Back Directory | [Name]
Benzamide, 4-(dimethylamino)-N-[[4-[(1E)-3-(hydroxyamino)-3-oxo-1-propen-1-yl]phenyl]methyl]- | [CAS]
617690-98-9 | [Synonyms]
SK 7041
SK-7041
Benzamide, 4-(dimethylamino)-N-[[4-[(1E)-3-(hydroxyamino)-3-oxo-1-propen-1-yl]phenyl]methyl]- | [Molecular Formula]
C19H21N3O3 | [MOL File]
617690-98-9.mol | [Molecular Weight]
339.39 |
| Hazard Information | Back Directory | [Description]
SK-7041 is a potent HDAC inhibitor. It acts by preferentially inhibiting class I HDAC1 and HDAC2. | [Uses]
SK-7041 is a HDAC inhibitor with the IC50 of 172 nM. SK-7041 induces the hyperacetylation of histones H3 and H4 .SK-7041 inhibits tumor cell growth in vivo and in vitro, induces cell apoptosis, and arrests cell cycle at the G1 phase[1]. | [References]
[1] Park JH, et al. Class I histone deacetylase-selective novel synthetic inhibitors potently inhibit human tumor proliferation. Clin Cancer Res. 2004;10(15):5271-5281. DOI:10.1158/1078-0432.CCR-03-0709 |
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