| Identification | Back Directory | [Name]
4-(1-benzofuran-2-ylcarbonyl)-1-{5-[(2-chlorobenzyl)sulfanyl]-1,3,4-thiadiazol-2-yl}-3-hydroxy-5-(4-hydroxy-3-methoxyphenyl)-1,5-dihydro-2H-pyrrol-2-one | [CAS]
618865-52-4 | [Synonyms]
Antibacterial agent 64
4-(1-benzofuran-2-ylcarbonyl)-1-{5-[(2-chlorobenzyl)sulfanyl]-1,3,4-thiadiazol-2-yl}-3-hydroxy-5-(4-hydroxy-3-methoxyphenyl)-1,5-dihydro-2H-pyrrol-2-one
2H-Pyrrol-2-one, 4-(2-benzofuranylcarbonyl)-1-[5-[[(2-chlorophenyl)methyl]thio]-1,3,4-thiadiazol-2-yl]-1,5-dihydro-3-hydroxy-5-(4-hydroxy-3-methoxyphenyl)- | [Molecular Formula]
C29H20ClN3O6S2 | [MOL File]
618865-52-4.mol | [Molecular Weight]
606.07 |
| Hazard Information | Back Directory | [Uses]
Antibacterial agent 64 (compound 62) is a potent YycG inhibitor (IC50=6.1 μM) and an antibacterial agent. Antibacterial agent 64 combines with ampicillin could synergistically eradicate the biofilm-embedded viable bacteria[1]. | [References]
[1] Chen Z, et al. Selection and Identification of Novel Antibacterial Agents against Planktonic Growth and Biofilm Formation of Enterococcus faecalis. J Med Chem. 2021;64(20):15037-15052. DOI:10.1021/acs.jmedchem.1c00939 |
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| Company Name: |
OTAVA chemicals
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416 305 9979 (Canada) |
| Website: |
www.otavachemicals.com |
| Company Name: |
Specs
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+31 15 251 8111 |
| Website: |
www.specs.net |
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