| Identification | Back Directory | [Name]
AZD-5904 | [CAS]
618913-30-7 | [Synonyms]
AZD-5904
AZ1;TX4;AZD5904
AZD5904
(AZD 5904
AZD5904,AZD-5904,Inhibitor,AZD 5904,Glutathione Peroxidase,inhibit
(R)-3-((Tetrahydrofuran-2-yl)methyl)-2-thioxo-1,2,3,9-tetrahydro-6H-purin-6-one
6H-Purin-6-one, 1,2,3,9-tetrahydro-3-[[(2R)-tetrahydro-2-furanyl]methyl]-2-thioxo- | [EINECS(EC#)]
642-433-3 | [Molecular Formula]
C10H12N4O2S | [MDL Number]
MFCD31619279 | [MOL File]
618913-30-7.mol | [Molecular Weight]
252.29 |
| Chemical Properties | Back Directory | [density ]
1.54±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
dmso:22.73(Max Conc. mg/mL);90.09(Max Conc. mM) | [form ]
A solid | [pka]
8.53±0.20(Predicted) | [color ]
White to yellow | [InChI]
1S/C10H12N4O2S/c15-9-7-8(12-5-11-7)14(10(17)13-9)4-6-2-1-3-16-6/h5-6H,1-4H2,(H,11,12)(H,13,15,17)/t6-/m1/s1 | [InChIKey]
RSPDBEVKURKEII-ZCFIWIBFSA-N | [SMILES]
O=C1NC(N(C[C@@H]2OCCC2)C3=C1NC=N3)=S |
| Hazard Information | Back Directory | [Uses]
(S)-3-((Tetrahydrofuran-2-yl)methyl)-2-thioxo-1,2,3,7-tetrahydro-6H-purin-6-one is used as an internal standard and also as an analytical standard. | [Biological Activity]
AZD5904 (TX4) is an orally active 2-thioxanthine class suicide substrate th at targets myeloperoxidase (MPO) for mechanism-based inactivationcovalently modifying MPO heme group without converting the enzyme to compound II. AZD5904 effectively inhibits peroxide-induced human MPO chlorination activity (IC50 = 0.2 μM) and extracellular MPO activity in PMA-stimulated human neutrophil cultures (by 68% at 1 μM). Oral administration (20-180 μmol/kg) of the racemate (TX3) is efficacious in reducing inflammation site MPO activity in mice in vivo with 10- to 19-fold selectivity over lactoperoxidase (LPO)thyroid peroxidase (TPO)and >70-fold selectivity over a panel of other enzymesion channelsand receptors. |
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| Company Name: |
BOC Sciences
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| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
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