| Identification | Back Directory | [Name]
1-phenoxazin-10-ylethanone | [CAS]
6192-43-4 | [Synonyms]
HJ-PI01
N-Acetylphenoxazine
10-acetylphenoxazine
1-phenoxazin-10-ylethanone
1 phenoxazin 10 ylethanone,1phenoxazin10ylethanone | [Molecular Formula]
C14H11NO2 | [MDL Number]
MFCD00093787 | [MOL File]
6192-43-4.mol | [Molecular Weight]
225.243 |
| Hazard Information | Back Directory | [Uses]
HJ-PI01 (10-Acetylphenoxazine) is an orally active Pim-2 inhibitor. HJ-PI01 induces apoptosis and autophagic cell death of cancer cells. HJ-PI01 inhibits tumor growth in MDA-MB-231 xenograft mice. HJ-PI01 can be used for cancer research[1]. | [in vivo]
HJ-PI01 (40 mg/kg; oral administration, once daily for 10 days) inhibits tumor growth in MDA-MB-231 xenograft mice[1]. | Animal Model: | BALB/c female nude mice with MDA-MB-231 cells injection[1] | | Dosage: | 40 mg/kg | | Administration: | Oral administration; 40 mg/kg, once daily for 10 days | | Result: | Significantly inhibited tumor growth with an obvious decreasing of the body, liver, spleen and kidney weights of the mice.
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| [References]
[1] Zhao YQ, et al. Characterization of HJ-PI01 as a novel Pim-2 inhibitor that induces apoptosis and autophagic cell death in triple-negative human breast cancer. Acta Pharmacol Sin. 2016 Sep;37(9):1237-50. DOI:10.1038/aps.2016.60 |
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