| Identification | Back Directory | [Name]
DOTA-NOC, DOTA-[Nal3]-octreotide | [CAS]
619300-53-7 | [Synonyms]
DOTA-NOC
DOTA-NOC acetate
DOTA-NOC, DOTA-[Nal3]-octreotide
L-Cysteinamide, N-[2-[4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododec-1-yl]acetyl]-D-phenylalanyl-L-cysteinyl-3-(1-naphthalenyl)-L-alanyl-Dtryptophyl-L-lysyl-L-threonyl-N-[(1R,2R)-2-hydroxy-1-(hydroxymethyl)propyl]-, cyclic(2)-disulfide
L-Cysteinamide, N-[[4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododec-1-yl]acetyl]-D-phenylalanyl-L-cysteinyl-3-(1-naphthalenyl)-L-alanyl-D-tryptophyl-L-lysyl-L-threonyl-N-[(1R,2R)-2-hydroxy-1-(hydroxymethyl)propyl]-, cyclic (2-7)-disulfide | [Molecular Formula]
C69H94N14O17S2
| [MDL Number]
MFCD20134059 | [MOL File]
619300-53-7.mol | [Molecular Weight]
1455.7 |
| Chemical Properties | Back Directory | [Appearance]
Colourless to off-white lyophilised solid | [solubility ]
PBS (pH 7.2): Sparingly soluble: 1-10 mg/ml | [Sequence]
DOTA-{d-Phe}-Cys-{Nal}-{d-Trp}-Lys-Thr-Cys-Thr-ol (Disulfide bridge: Cys2-Cys7) | [InChIKey]
VMOLIPGHXGTESU-UHFFFAOYSA-N | [CAS DataBase Reference]
619300-53-7 |
| Hazard Information | Back Directory | [Chemical Properties]
Colourless to off-white lyophilised solid | [Uses]
DOTA-NOC (DOTA-Nal3-octreotide) is a high-affinity ligand of somatostatin receptor subtypes 2, 3 and 5. DOTA-NOC can be used for labeling with various radiometals, and development of radiopeptide imaging[1]. DOTA-NOC can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs). | [IC 50]
RDC Peptide | [References]
[1] Wild D, et al. DOTA-NOC, a high-affinity ligand of somatostatin receptor subtypes 2, 3 and 5 for labelling with various radiometals. Eur J Nucl Med Mol Imaging. 2003 Oct;30(10):1338-47. DOI:10.1007/s00259-003-1255-5 |
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