| Identification | Back Directory | [Name]
TRIHEPTANOIN | [CAS]
620-67-7 | [Synonyms]
triheptylin
TRIHEPTANION
TRIHEPTANOIN
TRIOENANTHIN
trienanthoin
tri-heptanoi
trioenanthoin
glycerol trienanthate
triheptanoicglyceride
glyceroltriheptanoate
GLYCERYL TRIHEPTANOATE
GLYCEROL TRIOENANTHATE
GLYCERINETRIHEPTANOATE
glyceryl trioenanthate
Glycerol-triheptanoate-
Camicinal Hydrochloride
1,2,3-Trienanthoylglycerol
Glycerol trienanthate >=94%
Propan-1,2,3-triyltrisheptanoat
1,2,3-Propanetriyl=triheptanoate
Propane-1,2,3-triyl triheptanoate
1,2,3-Propanetriol trisheptanoate
propane-1,2,3-triyl trisheptanoate
1-O,2-O,3-O-Triheptanoyl-L-glycerol
heptanoicacid,1,2,3-propanetriylester
Triheptanoic acid 1,2,3-propanetriyl ester
1,3-di(heptanoyloxy)propan-2-yl heptanoate
Glyceroltriheptanoate,1,2,3-propanetriylester
Heptanoic acid 1,1',1''-(1,2,3-propanetriyl) ester
enanthic acid [2-enanthyloxy-1-(enanthyloxymethyl)ethyl] ester | [EINECS(EC#)]
210-647-2 | [Molecular Formula]
C24H44O6 | [MDL Number]
MFCD00042910 | [MOL File]
620-67-7.mol | [Molecular Weight]
428.6 |
| Chemical Properties | Back Directory | [Appearance]
colourless liquid | [Boiling point ]
200 °C(Press: 1 Torr) | [density ]
0.966 g/mL at 20 °C(lit.)
| [refractive index ]
n20/D 1.444
| [storage temp. ]
Store at -20°C, protect from light | [solubility ]
DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml | [form ]
A liquid | [color ]
Colorless to light yellow | [Stability:]
Stable. Incompatible with strong oxidizing agents. | [Cosmetics Ingredients Functions]
SKIN CONDITIONING - OCCLUSIVE
VISCOSITY CONTROLLING | [InChI]
InChI=1S/C24H44O6/c1-4-7-10-13-16-22(25)28-19-21(30-24(27)18-15-12-9-6-3)20-29-23(26)17-14-11-8-5-2/h21H,4-20H2,1-3H3 | [InChIKey]
PJHKBYALYHRYSK-UHFFFAOYSA-N | [SMILES]
C(OC(=O)CCCCCC)C(OC(=O)CCCCCC)COC(=O)CCCCCC | [LogP]
8.86 at 22℃ | [Uses]
triheptanoin is a triglyceride that acts as a surfactant and skinconditioning agent, it also helps increase product viscosity. often used in cleansers, face and neck products, moisturizers and lipsticks. | [CAS DataBase Reference]
620-67-7 | [EPA Substance Registry System]
Heptanoic acid, 1,1',1''-(1,2,3-propanetriyl) ester (620-67-7) |
| Hazard Information | Back Directory | [Chemical Properties]
colourless liquid | [Flammability and Explosibility]
Nonflammable | [Biological Activity]
Triheptanoin is a triglyceride with 3 molar eq. of saturated heptanoic acid (C7:0). The even-chain FA does not occur naturally and is able to bypass metabolic block induced by enzyme deficiency and to replenish reduced tricarboxylic acid/TCA-cycle (Krebs cycle or citric acid cycle/CAC) intermediates (anaplerosis) in vivo. | [in vivo]
In long-chain fatty acid oxidation disorders (LC-FAOD), Triheptanoin is used as an anaplerotic compound, acting as a source of calories and fatty acids to bypass the LC-FAOD enzyme deficiencies[1].
Triheptanoin can be used for the research of ataxia-telangiectasia (A-T)[2].
Triheptanoin functions as an anaplerotic agent replenishing tricarboxylic acid (TCA) cycle intermediates by metabolism to heptanoate (C7) and subsequently acetyl-CoA and propionyl-CoA that feed into the TCA cycle to supply energy[2].
Triheptanoin mitigates brain ATP depletion and mitochondrial dysfunction, including respiration and redox balance in a mouse model of Alzheimer's disease, supporting the energy failure hypothesis for that disorder[2].
Triheptanoin (Mice were treated with Triheptanoin (35E%) for 10 days prior to pilocarpine injection to induce status epilepticus) preserved mitochondrial functions in the hippocampal formations of pilocarpine-induced status epilepticus (SE) mice[3]. | Animal Model: | 7-8 week old male CD1 (35-40 g)[3] | | Dosage: | 35E% oral Triheptanoin was mixed into mouse chow | | Administration: | Given 35E% Triheptanoin treatment 10 days prior to SE induction | | Result: | Preserved mitochondrial functions in SE mice. |
| [storage]
Store at -20°C, protect from light |
|
| Company Name: |
Sigma-Aldrich
|
| Telephone: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
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