| Identification | Back Directory | [Name]
ETHYL2-(4-HYDROXYPYRIMIDIN-5-YL)ACETATE | [CAS]
6214-46-6 | [Synonyms]
ETHYL2-(4-HYDROXYPYRIMIDIN-5-YL)ACETATE
ethyl 2-(6-oxo-1H-pyrimidin-5-yl)acetate
4-Hydroxy-5-pyrimidineacetic acid ethyl ester
ethyl 2-(6-oxo-1,6-dihydropyriMidin-5-yl)acetate
2-(6-oxo-1H-pyrimidin-5-yl)acetic acid ethyl ester
5-Pyrimidineaceticacid, 3,4-dihydro-4-oxo-, ethyl ester
ETHYL2-(4-HYDROXYPYRIMIDIN-5-YL)ACETATE ISO 9001：2015 REACH | [EINECS(EC#)]
604-604-1 | [Molecular Formula]
C8H10N2O3 | [MDL Number]
MFCD11656636 | [MOL File]
6214-46-6.mol | [Molecular Weight]
182.18 |
| Chemical Properties | Back Directory | [Melting point ]
155-156 °C | [density ]
1.27±0.1 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Room Temperature | [pka]
8.62±0.40(Predicted) | [Appearance]
White to off-white Solid |
| Hazard Information | Back Directory | [Synthesis]
The ethanolic solution of sodium ethoxide was cooled to 0 °C under argon protection. Under continuous stirring, diethyl 2-formylsuccinate was slowly added. after 5 minutes, the corresponding formamidine acetate was added drop by drop while maintaining the condition of 0°C. Subsequently, the reaction mixture was warmed up to room temperature and stirred continuously for 3 days. After completion of the reaction, 5% aqueous hydrogen chloride solution was added and stirring was continued for 30 minutes. After addition of appropriate amount of water, ethanol was removed by distillation under reduced pressure at 30 °C. Finally, the precipitate was collected by filtration to afford the target product ethyl 4-hydroxy-5-pyrimidineacetate (Compound 1, where X = H, Me, Ph, SMe; Y = H, R1 = Et). | [References]
[1] Monatshefte fur Chemie, 2016, vol. 147, # 4, p. 767 - 773 |
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