| Identification | Back Directory | [Name]
(-)-4-BROMOTETRAMISOLE OXALATE | [CAS]
62284-79-1 | [Synonyms]
R 30402
6-BROMOLEVAMISOLE OXALATE
L-P-BROMOTETRAMISOLE OXALATE
(-)-P-BROMOLEVAMISOLE OXALATE
(-)-P-BROMOTETRAMISOLE OXALATE
(-)-4-BROMOTETRAMISOLE OXALATE
L-(-)-P-BROMOTETRAMISOLE OXALATE
(S)-(-)-4-BROMOTETRAMISOLE OXALATE
(-)-P-BROMOTETRAMISOLE OXALATE SALT
(-)-4-bromotetramisole oxalate salt
L(-)-p-Bromotetramisole oxalate,99%
(-)-p-Bromotetramosole Oxalate Salt
(S)-6-(p-bromophenyl)-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole oxalate
S(-)-6-(4-BROMOPHENYL)-2,3,5,6-TETRAHYDROIMIDAZO[2,1-B]THIAZOLE OXALATE
(-)-(S)-6-(4-BROMOPHENYL)-2,3,5,6-TETRAHYDROIMIDAZO[2,1-B]THIAZOLE OXALATE
6-(4-Bromophenyl)-2,3,5,6-tetrahydro-(6S)-imidazo[2,1-b]thiazole,ethanedioate (1:1)
(-)-6(4-BROMOPHENYL)-2,3,5,6-TETRAHYDROIMIDAZO[2,1-B]THIAZOLE ETHANEDIOATE OXALATE SALT
(-)-4-Bromotetramisole oxalate, 6-Bromolevamisole oxalate, S(-)-6-(4-Bromophenyl)-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole oxalate
(-)-p-Bromotetramisole oxalate salt, 6-Bromolevamisole oxalate salt, (S)-(-)-6-(4-Bromophenyl)-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole oxalate salt | [EINECS(EC#)]
263-487-0 | [Molecular Formula]
C13H13BrN2O4S | [MDL Number]
MFCD00070406 | [MOL File]
62284-79-1.mol | [Molecular Weight]
373.22 |
| Chemical Properties | Back Directory | [Appearance]
white to light yellow crystal powde | [Melting point ]
192 °C (dec.)
| [Fp ]
87℃ | [storage temp. ]
2-8°C | [solubility ]
Soluble in Water (up to 10 mg/ml) | [form ]
liquid | [color ]
White | [Optical Rotation]
[α]25/D 104°, c = 0.5 in H2O | [BRN ]
4944883 | [Stability:]
Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 3 months. | [InChI]
InChI=1/C11H11BrN2S.C2H2O4/c12-9-3-1-8(2-4-9)10-7-14-5-6-15-11(14)13-10;3-1(4)2(5)6/h1-4,10H,5-7H2;(H,3,4)(H,5,6)/t10-;/s3 | [InChIKey]
ZULBIBHDIQCNIS-MEQOOBBNNA-N | [SMILES]
C(=O)(O)C(=O)O.BrC1C=CC([C@@H]2N=C3SCCN3C2)=CC=1 |&1:11,r| |
| Hazard Information | Back Directory | [Chemical Properties]
white to light yellow crystal powde | [Description]
Four distinct human isoenzymes of alkaline phosphatase (AP) are known: intestinal (IAP), placental (PLAP), tissue non-specific (NSAP, also known as liver/bone/kidney AP), and germ cell AP (also known as placental-like AP, PLAP-like).1 L-p-Bromotetramisole is a cell-permeable inhibitor of all four human AP isoenzymes (Kis =18 and 56 μM for PLAP and NSAP, respectively).1,2,3,4 While PLAP is strongly inhibited by L-p-bromotetramisole, a second AP, possibly PLAP-like, shows only partial inhibition.3 L-p-Bromotetramisole has been shown to inhibit a tyrosine phosphatase from Drosophila and, as a result, is also used as a tyrosine phosphatase inhibitor.5,6 | [Uses]
L-p-Bromotetramisole Oxalate or (-)-p-Bromotetramisole Oxalate is a potent inhibitor of alkaline phosphatase. | [Biochem/physiol Actions]
(-)-p-Bromolevamisole oxalate inhibits L-isoforms of alkaline phosphatases. | [target]
alkaline phosphatase | [References]
1) Kovach?et al. (1992),?Levamisole potentiation of fluorouracil antiproliferative activity mimicked by orthovanadate, an inhibitor of tyrosine phosphatase; J. Natl. Cancer Inst.,?84?515
2) Luo et al. (2000),?Role of protein phosphatases in the activation of CTFR (ABCC7) by genistein and bromotetramisole;?Am. J. Physiol. Cell Physiol.,?279?C108
3) Scher?et al.?(1998),?The phosphatase inhibitors, orthovanadate and levamisole, inhibit induction of erythroid differentiation and abrogate the associated inhibition of glycolysis; Int. J. Oncol.,?12?987 |
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Energy Chemical
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T&W GROUP
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Sigma-Aldrich
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Twochem Co.Ltd
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