| Identification | Back Directory | [Name]
Wee1 Inhibitor | [CAS]
622855-37-2 | [Synonyms]
WEE1-IN-4
Wee1 Inhibitor
Pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione, 4-(2-chlorophenyl)-9-hydroxy- | [Molecular Formula]
C20H11ClN2O3 | [MOL File]
622855-37-2.mol | [Molecular Weight]
362.77 |
| Hazard Information | Back Directory | [Uses]
WEE1-IN-4 (Compound 15) is a potent checkpoint Wee1 kinase inhibitor with an IC50 of 0.011 μM. Wee1 inhibitors can abrogate the G2/M checkpoint[1]. | [Biological Activity]
Wee1 inhibitor is an inhibitor of the checkpoint kinase Wee1 (IC50 = 11 nM).1 It is selective for Wee1 over checkpoint kinase 1 (Chk1; IC50 = 440 nM). Wee1 inhibitor also inhibits the ATPase activity of LptB, an enzyme involved in the transport and assembly of LPS (IC50 = 25 μM for the E. coli enzyme).2 | [References]
1.Palmer, B.D., Thompson, A.M., Booth, R.J., et al.4-Phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione inhibitors of the checkpoint kinase Wee1. Structure-activity relationships for chromophore modification and phenyl ring substitutionJ. Med. Chem.49(16)4896-4911(2006)
2.Gronenberg, L.S., and Kahne, D.Development of an activity assay for discovery of inhibitors of lipopolysaccharide transportJ. Am. Chem. Soc.132(8)2518-2519(2010)
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| Company Name: |
Merck KGaA
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| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
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