| Identification | Back Directory | [Name]
ISOPROPYL GLYCOLATE | [CAS]
623-61-0 | [Synonyms]
isopropyl glycolat
ISOPROPYL GLYCOLATE
isopropyl hydroxyacetate
1-carbamoyl-3-propylurea
Isopropyl 2-hydroxyacetate
2-hydroxy-3-Methylbutanoate
Propan-2-yl 2-hydroxyacetate
Glycolic acid isopropyl ester
propan-2-yl 2-hydroxyethanoate
Hydroxyacetic acid isopropyl ester
2-hydroxyacetic acid isopropyl ester
ISOPROPYL GLYCOLATE ISO 9001：2015 REACH | [EINECS(EC#)]
210-804-5 | [Molecular Formula]
C5H10O3 | [MDL Number]
MFCD00046747 | [MOL File]
623-61-0.mol | [Molecular Weight]
118.13 |
| Chemical Properties | Back Directory | [Boiling point ]
159.3±8.0 °C(Predicted) | [density ]
1.050±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [pka]
13.21±0.10(Predicted) | [Appearance]
Colorless to light yellow Liquid | [Water Solubility ]
Slightly soluble in water. |
| Hazard Information | Back Directory | [Uses]
Isopropyl glycolate is used as pharmaceutical intermediate. | [Synthesis]
The general procedure for the synthesis of isopropyl hydroxyacetate from dimethyl oxalate was as follows: first, the hydrogenation of the ester compound was carried out using bipyridyltetraethylruthenium complex 5 as a catalyst. The specific reaction conditions were as follows: the ratio of substrate to catalyst (S/C) was 1000, the amount of substrate was 3.0 mmol, the amount of catalyst 5 was 3.0 μmol, the solvent was 3.0 mL of isopropanol (iPrOH), and 0.3 mmol of sodium methanol (NaOMe) was added as the base, and the hydrogen pressure was 5 MPa, and the temperature of the reaction was 25 ℃. The reaction results are detailed in Table 2, which lists the hydrogenation results of other ester compounds under the same conditions. | [References]
[1] Patent: CN103980317, 2017, B. Location in patent: Paragraph 0098; 0099; 0100; 0102; 0104 |
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