| Identification | Back Directory | [Name]
KU-0058684 | [CAS]
623578-11-0 | [Synonyms]
KU-0058684
2,5-Pyrrolidinedione, 1-[5-[(3,4-dihydro-4-oxo-1-phthalazinyl)methyl]-2-fluorophenyl]- | [Molecular Formula]
C19H14FN3O3 | [MDL Number]
MFCD12756382 | [MOL File]
623578-11-0.mol | [Molecular Weight]
351.33 |
| Hazard Information | Back Directory | [Description]
KU-0058684 is a potent PARP and DNA-PK inhibitors. | [Uses]
KU-0058684 is a potent PARP inhibitor, with an IC50 of 3.2 nM for PARP-1. KU-0058684 significantly reduces DNA double strand break (DSB) repair[1][2]. | [IC 50]
PARP-1: 3.2 nM (IC50) | [References]
[1] Mitchell J, et al. Poly(ADP-Ribose) polymerase-1 and DNA-dependent protein kinase have equivalent roles in double strand break repair following ionizing radiation. Int J Radiat Oncol Biol Phys. 2009 Dec 1;75(5):1520-7. DOI:10.1016/j.ijrobp.2009.07.1722
[2] McCabe N, et al. BRCA2-deficient CAPAN-1 cells are extremely sensitive to the inhibition of Poly (ADP-Ribose) polymerase: an issue of potency. Cancer Biol Ther. 2005 Sep;4(9):934-6. DOI:10.4161/cbt.4.9.2141 |
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