| Identification | Back Directory | [Name]
PROPYNAL | [CAS]
624-67-9 | [Synonyms]
PROPYNAL
Prorynal
2-propynal
prop-2-ynal
2-Propyn-1-al
PROPIOALDEHYDE
PROPYNAL TECH.
2-Propyne-1-one
Propiolaldehyde
Propiolic aldehyde
2-Propynal (>85%, stabilized with Hydroquinone) | [EINECS(EC#)]
210-857-4 | [Molecular Formula]
C3H2O | [MDL Number]
MFCD00040470 | [MOL File]
624-67-9.mol | [Molecular Weight]
54.05 |
| Chemical Properties | Back Directory | [Melting point ]
121-122 °C | [Boiling point ]
58.85°C | [density ]
0.9152 | [refractive index ]
1.3963 (estimate) | [solubility ]
Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol | [form ]
Oil | [color ]
Colourless to Orange | [Stability:]
Light Sensitive, Moisture Sensitive, Volatile | [EPA Substance Registry System]
2-Propynal (624-67-9) |
| Hazard Information | Back Directory | [Uses]
2-Propynal is hypothesized to be a possible metabolite of pargyline, a monoamine oxidase inhibitor that is used as an antihypertensive agent. 2-Propynal is also known to induce hepatocyte toxicity in vivo in rats. | [Definition]
ChEBI: Prop-2-ynal is a ynal and a terminal acetylenic compound. It has a role as a mouse metabolite. | [Synthesis Reference(s)]
1. Sauer, J. C. OSC 1962, 4, 813.
2. See also: Ghelfi, F.; Grandi, R.; Pagnoni, U. M. SC 1992, 22, 1845.
| [Synthesis]
Propynal is most simply synthesized by oxidation of Propargyl Alcohol.1,2
| [Enzyme inhibitor]
This aldehyde (FW = 54.048 g/mol; CAS 624-67-9), also known as propynal, synthesized from propargyl alcohol, is an irreversible inhibitor of aldehyde dehydrogenases. | [storage]
It is recommended that handling of propynal should include the use of a nonglass container and dilution with a sufficient volume of an inert solvent to absorb the heat of polymerization without boiling, e.g. <=10% in toluene. Use in a fume hood.
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