| Identification | Back Directory | [Name]
4-CHLORO-6,7-DIFLUOROQUINAZOLINE | [CAS]
625080-60-6 | [Synonyms]
Quinazoline, 4-chloro-6,7-difluoro- | [Molecular Formula]
C8H3ClF2N2 | [MDL Number]
MFCD06657230 | [MOL File]
625080-60-6.mol | [Molecular Weight]
200.57 |
| Chemical Properties | Back Directory | [Boiling point ]
290.9±35.0 °C(Predicted) | [density ]
1.538±0.06 g/cm3(Predicted) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2-8°C | [pka]
-0.04±0.70(Predicted) | [Appearance]
White to light yellow Solid |
| Hazard Information | Back Directory | [Synthesis]
Example 4A Step 2: 6,7-difluoro-4-hydroxyquinazoline (910 mg, 5 mmol) was added to trichlorophos (15 mL) followed by triethylamine (700 μL, 5 mmol). The reaction mixture was heated to reflux at 100 °C for 4 h. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure. The resulting solid was ground with ethyl acetate (2 × 100 mL), and the combined organic phases were rapidly filtered through a silica gel column to afford 4-chloro-6,7-difluoroquinazoline (870 mg, 4.35 mmol, 87% yield). m/z 201 ([M + H]+) by LC-MS (ESI). | [References]
[1] Patent: WO2009/117080, 2009, A1. Location in patent: Page/Page column 165
[2] Patent: US2006/281772, 2006, A1. Location in patent: Page/Page column 131 |
|
| Company Name: |
Shanghai Ennopharm Co., Ltd.
|
| Telephone: |
+86 (21) 6435-5022 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList13640/0_EN.htm |
| Company Name: |
SynAsst Chemical.
|
| Telephone: |
021-60343070 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList15848/0_EN.htm |
| Company Name: |
NovoChemy Ltd.
|
| Telephone: |
86-(0)21-31261262 373522135 |
| Website: |
www.novochemy.com |
|