| Identification | Back Directory | [Name]
2-Pyrrolidinecarbonitrile, 4-fluoro-1-[2-[(2-hydroxy-1,1-dimethylethyl)amino]acetyl]-, (2S,4S)- | [CAS]
625110-37-4 | [Synonyms]
DPP-IV-IN-1
DPPIVIN1,DPP IV IN 1
2-Pyrrolidinecarbonitrile, 4-fluoro-1-[2-[(2-hydroxy-1,1-dimethylethyl)amino]acetyl]-, (2S,4S)- | [Molecular Formula]
C11H18FN3O2 | [MDL Number]
MFCD31544437 | [MOL File]
625110-37-4.mol | [Molecular Weight]
243.278 |
| Chemical Properties | Back Directory | [Boiling point ]
472.3±45.0 °C(Predicted) | [density ]
1.20±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
15.49±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
DPP-IV-IN-1 is a potent inhibitor of dipeptidyl peptidase IV (DPP-IV), a highly specific serine protease, with an IC50 of 4.6 nM. | [in vivo]
DPP-IV-IN-1 (0.1 and 0.3 mg/kg, p.o.) reduces the increase in plasma glucose beginning 30 min after glucose loading, and significantly suppresses hyperglycemia at the dose of 0.3 mg/kg in a rat model of obesity and impaired glucose tolerance. The effect is based on its inhibitory effect on plasma DPP-IV activity[1]. | [IC 50]
DPP-4 | [storage]
Store at -20°C | [References]
[1] Fukushima H, et al. Synthesis and structure-activity relationships of potent 4-fluoro-2-cyanopyrrolidine dipeptidyl peptidase IV inhibitors. Bioorg Med Chem. 2008 Apr 1;16(7):4093-106. DOI:10.1016/j.bmc.2008.01.016 |
|
| Company Name: |
BOC Sciences
|
| Tel: |
|
| Website: |
https://www.bocsci.com |
|