| Identification | Back Directory | [Name]
FROXIPROST | [CAS]
62559-74-4 | [Synonyms]
ONO-995
FROXIPROST
(2E,5Z)-7-[(1R)-3α,5α-Dihydroxy-2β-[(E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]-1-butenyl]cyclopentyl]-2,5-heptadienoic acid methyl ester
(2E,5Z)-7-[(1R)-3α,5α-Dihydroxy-2β-[(E,R)-3-hydroxy-4-(3-trifluoromethylphenoxy)-1-butenyl]cyclopentan-1α-yl]-2,5-heptadienoic acid methyl ester
(2E,5Z)-7-[(1R)-3α,5α-Dihydroxy-2β-[(1E,3R)-3-hydroxy-4-(m-trifluoromethylphenoxy)-1-butenyl]cyclopentan-1α-yl]-2,5-heptadienoic acid methyl ester
(2E,5Z)-7-[(1R)-3α,5α-Dihydroxy-2β-[(E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]-1-butenyl]cyclopentan-1α-yl]-2,5-heptadienoic acid methyl ester
2,5-Heptadienoic acid, 7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]-1-buten-1-yl]cyclopentyl]-, methyl ester, (2E,5Z)- | [Molecular Formula]
C24H29F3O6 | [MDL Number]
MFCD00868749 | [MOL File]
62559-74-4.mol | [Molecular Weight]
470.48 |
| Hazard Information | Back Directory | [Uses]
Froxiprost (ONO-995) is a PGF2α (HY-12956) analogue. Froxiprost stimulates thymidine uptake, 1,2 diacylglycerol (1,2-DAG) accumulation, and phosphorylcholine formation in osteoblast-like MC3T3-E1 cells[1]. | [References]
[1] Sakai T, et al. Involvement of phosphatidylcholine hydrolysis by phospholipase C in prostaglandin F2alpha-induced 1,2-diacylglycerol formation in osteoblast-like MC3T3-E1 cells. J Bone Miner Metab. 2004;22(3):198-206. DOI:10.1007/s00774-003-0470-2 |
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